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Post-doc: Light Sheet Imaging of Synapse Development in Zebrafish

Designing instrumentation for in vivo imaging, light sheet microscopy to investigate how synapses form in the developing zebrafish brain

11 maanden geleden


Mekelweg, Delft, Zuid-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
€ 4084 per maand


A post-doctoral position in Imaging Physics is available at Delft University of Technology to work at the interface of optical physics and neuroscience, designing instrumentation for in vivo imaging applications.
Light sheet fluorescence imaging is a fast method to image dynamic signals in semi-transparent organisms, like larval zebrafish. We will use light sheet microscopy to investigate how synapses form in the developing zebrafish brain. The goal of the project is to design and implement a light sheet microscope based on Photo-Activation Localisation Microscopy (PALM) which will be capable of sub-diffraction-limited resolution measurements of transient intracellular signals (e.g., calcium and voltage) in single neurons. The light sheet microscope will interface with an independent light path to perform optogenetic manipulations while simultaneously imaging synaptic responses.


The successful candidate will have recently completed a PhD in biophysics, optics, or neuroscience, and have significant experimental experience with imaging and optics. Experience with fluorescence microscopy and instrumentation design is highly desirable. Programming skills in either Matlab, Labview, or Python are required. Experience with animal research is desirable.      


The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

For more information about this position, please contact Dr. E.C.M. Carroll, phone: +31 (0)15-2787596, e-mail: e.c.m.carroll@tudelft.nl. To apply, please e-mail a detailed CV along with a letter of application by 15 January 2018 to Dr. E.C.M. Carroll, e.c.m.carroll@tudelft.nl.
When applying for this position, please refer to vacancy number TNWIP17-060.

Additional information

Dr. E.C.M. Carroll
+31 (0)15-2787596

Technische Universiteit Delft


Delft University of Technology (the TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. The TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At the TU Delft you will work in an environment where technical sciences and society converge. The TU Delft comprises eight faculties, unique laboratories, research institutes and schools. Applied Sciences The Faculty of Applied Sciences has a strong programme in Imaging Physics in which new instrumentation and new methods are developed for microscopy and medical imaging. To accommodate this programme, a new research lab is being built. Most of the instruments in the lab are prototypes with unique functionalities. Once in operation, scientific and industrial users will be invited for evaluation and first scientific observations. We are looking for one post-doctoral researcher to work in this new lab.