Ongeveer 16 uur geleden - Technische Universiteit Delft (TUD) - Delft
The PhD project is part of a European Network with altogether 11 PhD projects on cutting-edge, multidisciplinary research, see …
Designing instrumentation for in vivo imaging, light sheet microscopy to investigate how synapses form in the developing zebrafish brain
A post-doctoral position in Imaging Physics is available at Delft University of Technology to work at the interface of optical physics and neuroscience, designing instrumentation for in vivo imaging applications.
Light sheet fluorescence imaging is a fast method to image dynamic signals in semi-transparent organisms, like larval zebrafish. We will use light sheet microscopy to investigate how synapses form in the developing zebrafish brain. The goal of the project is to design and implement a light sheet microscope based on Photo-Activation Localisation Microscopy (PALM) which will be capable of sub-diffraction-limited resolution measurements of transient intracellular signals (e.g., calcium and voltage) in single neurons. The light sheet microscope will interface with an independent light path to perform optogenetic manipulations while simultaneously imaging synaptic responses.
The successful candidate will have recently completed a PhD in biophysics, optics, or neuroscience, and have significant experimental experience with imaging and optics. Experience with fluorescence microscopy and instrumentation design is highly desirable. Programming skills in either Matlab, Labview, or Python are required. Experience with animal research is desirable.
Delft University of Technology (the TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. The TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At the TU Delft you will work in an environment where technical sciences and society converge. The TU Delft comprises eight faculties, unique laboratories, research institutes and schools. Applied Sciences The Faculty of Applied Sciences has a strong programme in Imaging Physics in which new instrumentation and new methods are developed for microscopy and medical imaging. To accommodate this programme, a new research lab is being built. Most of the instruments in the lab are prototypes with unique functionalities. Once in operation, scientific and industrial users will be invited for evaluation and first scientific observations. We are looking for one post-doctoral researcher to work in this new lab.