1 dag geleden - Universiteit van Amsterdam (UvA) - Amsterdam
The Amsterdam School for Cultural Analysis (ASCA), one of the six research schools of the Faculty of Humanities, currently has a vacant postdoctoral position …
Biochemical reaction networks with bi-stable dynamics
Mathematical models describing the kinetics of biochemical reaction networks are becoming increasingly detailed. The large number of coupled nonlinear ordinary differential equations constituting these detailed models complicates analysis of their dynamics, in particular, assessment of stability and bifurcation. Model reduction aims at elimination of complexes and reactions of a detailed biochemical reaction network, thereby producing a simpler biochemical reaction network that still captures the essential dynamics and is accessible for analysis.
This project focuses on model reduction of biochemical reaction networks with bi-stable dynamics, i.e. the state-space contains two stable attractors. Bi-stability is at the origin of many phenomena in (cell) biology, such as cell differentiation. Synthetic biology produces bi-stable toggle switches that enable advanced regulatory and computational functionality. It is therefore of utmost importance that bi-stability is preserved in the model reduction process.
To address these challenges we will develop advanced model reduction methods that exploit structural properties of biochemical reaction networks with bi-stability. The novel model reduction method will be tested on a recently developed and experimentally realised DNA-based toggle switch.
Applicants should have the following qualifications:
• A PhD degree in systems and control, applied mathematics, or systems biology
• A strong interest in mathematical modelling of (bio)chemical systems and the ability to do interdisciplinary research
• Basic programming skills in Matlab
• Good command of the English language and communication skills.
Delft University of Technology (the TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. The TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At the TU Delft you will work in an environment where technical sciences and society converge. The TU Delft comprises eight faculties, unique laboratories, research institutes and schools. Mechanical, Maritime and Materials Engineering The Delft Centre for Systems and Control (DCSC) coordinates the education and research activities in systems and control at Delft University of Technology. The Centre's research mission is to conduct fundamental research in systems dynamics and control, involving dynamic modelling, advanced control theory, optimisation, and signal analysis. The research is motivated by advanced technology development in physical imaging systems, robotics, and transportation systems.