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Post-doc positions in Biophysics of Eukaryotic Replication

In this project you will take on the novel and exciting challenge of understanding eukaryotic replication at the single-molecule level. As an independent and …

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Van der Maasweg, Delft, Zuid-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
€ 2984 - € 4084 per maand


In this project you will take on the novel and exciting challenge of understanding eukaryotic replication at the single-molecule level. As an independent and motivated post-doctoral researcher, your foremost responsibility will be towards knowledge creation of processes central to DNA replication, focusing in particular roles of the replicative helicases and the interactions between the three key polymerases. In doing so, you will be expected to master our state-of-the-art single-molecule force spectroscopy and fluorescence imaging systems capable of acquiring large datasets under a variety of different conditions. Your critical thinking will also be encouraged towards bringing in new technical expertise if required for the overall research progress. You will be involved in the purification and labelling of proteins as necessary and will analyse the imaged datasets using advanced image processing and biophysical modelling. You will extensively interact with collaborators in the highly renowned Diffley Lab, located at the Francis Crick institute in London.


We are looking to hire several outstanding experimentalist post-doctoral researchers who would like to build an exciting career with us in interdisciplinary biophysics focused on understanding mechanistic aspects of DNA replication using single-molecule methods. Probing DNA replication will entail quantitative analysis of microscopy data, deep contextual understanding of literature, an ability to employ different and ever-advancing technologies to one’s research question, the personality balance of exhibiting critical thinking while also being a team player, and the combination of long-term foresight and short-term planning. A strong background in quantitative biochemistry, biophysics, or structural biology is a necessity. A good command of spoken and written English is a must.


TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

For more information about this position, or to submit an application, please contact Prof. Dr. Nynke Dekker, phone: +31 (0)15-2783219, e-mail: n.h.dekker@tudelft.nl. Applications should include a letter of application, a detailed CV, and the names and contact information of three references. The deadline for applications is 30 April 2018. When applying for this position, please refer to vacancy number TNWBN18-018.

Additional information

Prof.Dr. Nynke Dekker
Phone: +31 (0)15 27 83219
E-mail: n.h.dekker@tudelft.nl