The group Molecular Biosensing for Medical Diagnostics (MBx, see www.tue.nl/mbx) at Eindhoven University of Technology (TU/e) creates ideas and generates scientific insights in the area of molecular biosensing with single-molecule resolution. This involves the engineering of molecular constructs for sensing applications (using protein, nucleic-acid, and protein-DNA technologies), methods to biofunctionalize nanoparticles, the development of novel single-molecule measurement methods, optical microscopies, particle characterization techniques, plasmonic effects, particle actuation principles, signal processing, and simulations. The research leads to novel methods for molecular biosensing, insights into protein function within complex and crowded environments, and novel routes into point-of-care and patient monitoring applications. The MBx group initiated and organizes the international competition on Sensors for Health (www.sensus.org). Laboratories are shared with the Chemical Biology research group (www.tue.nl/cb) and the Institute for Complex Molecular Systems (www.tue.nl/icms).
The two PhD projects focus on the development of a new technology for continuous biochemical monitoring. The technology is based on the tracking of the motion of particles that are molecularly tethered to a substrate, where modulations of the motion indicate the presence of single biomarker molecules. You will investigate the feasibility to accurately monitor biomarkers by a sandwich binding format and by a competitive binding format. You will develop tools to model and analyze data from hundreds to thousands of particles at the same time. The assays will be studied in buffer and in blood plasma filtrates. Important application areas in healthcare are intensive care medicine, therapeutic drug monitoring, peri-operative monitoring, and chronic organ disease. The PhD positions are part of a collaboration between the MBx group, the Chemical Biology and Protein Engineering group, the Theory of Polymers and Soft Matter group, Leiden University Medical Center, and three companies: Medtronic, Future Diagnostics, and Anteryon.
We are looking for enthusiastic candidates who are in an MSc program or who already have an MSc degree, preferably in Chemistry, Physics, Biomedical Engineering, or Nanotechnology. An interest in Physical Chemistry or Biophysics is required. Experience in advanced microscopies or single-molecule methods is a plus.
We offer:A challenging job at a dynamic and ambitious University and in an enthusiastic team.
An appointment (1 fte) as a PhD-student for four years, starting date: flexible, but preferably as soon as possible.
Gross monthly salaries are in accordance with the Collective Labour Agreement of the Dutch Universities (CAO NU), increasing from € 2222 per month initially, to € 2840 in the fourth year.
An attractive package of fringe benefits, including excellent work facilities, end of the year allowance and sports facilities.
Information and application
More information can be obtained from Prof. M.W.J. Prins, Molecular Biosensing for Medical Diagnostics, Dept. of Biomedical Engineering and Dept. of Applied Physics and, Eindhoven University of Technology. Phone +31 40 247 4018, email@example.com
. Application If you are interested in a PhD position and would like to apply, we request you to use the button "Apply now".
Your application can be addressed to prof. M.W.J. Prins. Applications must include all of the following: (i) a personal motivation letter, (ii) a Curriculum Vitae including the names and contact details of at least two references, (iii) transcripts of BSc and MSc degrees with courses and grades, (iv) a digital copy of BSc and MSc theses (if these are very large, you can send them by email)
Only complete applications will be considered. Screening of applicants will start as soon as applications are received and will continue until the position has been filled.