PhD in mammalian synthetic biology
The Eindhoven University of Technology (TU/e) has the following vacancy: PhD in Mammalian synthetic biology within the department of Biomedical Engineering (BME).
- de Rondom, Eindhoven, Noord-Brabant
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 38 uur
We are searching for a young scientist who is interested in the programming of new functions into mammalian cells to develop living sensor-actuator devices that can recognize and respond to diverse chemical inputs. The position is part of the NWO-VIDI project NanoSyn. You will learn to reprogram cells to respond to peptide-based stimuli and use this technology to develop a distributed cellular computing platform. The ultimate aim of this project is to develop synthetic mammalian cell devices, each with well-defined computational instructions that execute multicellular logic functions. The project will benefit of international collaborations with groups active in the field of mammalian synthetic biology.
About Eindhoven University of Technology (TU/e):
The TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, with close links to healthcare and industry. The TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.
About the Department of Biomedical Engineering (BME):
The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters Biomedical Engineering, Medical Sciences and Technology and Medical Engineering in its Graduate Program. Research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modeling. The department has more than 800 students and up to 200 tenured and non-tenured employees.
About the Institute for Complex Molecular Systems (ICMS):
The Institute for Complex Molecular Systems is an interdisciplinary institute at Eindhoven University of Technology (TU/e) which brings excellent researchers from different areas together to promote crossbreeding of ideas across disciplines in the departments Biomedical Engineering, Applied Physics, Chemical Engineering and Chemistry, Mathematics and Computer Science, and Mechanical Engineering. The institute aims to create and study biologically relevant functional structures with the ultimate goal of understanding the complexity of life.
About Synthetic Biology:
Work in the Synthetic Biology and Molecular Programming group (7 PhD students, 2 post-docs) is directed at the bottom-up construction of basic cellular functions from well-characterized biological components, and the development of novel biological computing devices that can enhance signalprocessing capabilities of natural and synthetic cells. This involves the design and construction of integrated genetic, protein or DNA-based circuits, either in a cell-free environment or in living cells, capable of autonomously performing useful functions. This multidisciplinary approach combines diverse research areas such as DNA/RNA nanotechnology, genetic engineering, and microengineering, guided by computational modeling and simulations of biochemical networks. Ultimately, advances in synthetic biology will allow the development of functional living and hybrid technologies such as biological robots, synthetic cells or augmented natural cells, that can be interfaced with the human body to detect disease biomarkers and allow autonomous, closed-loop therapeutic functions. Laboratories are shared with the Computational Biology, Chemical Biology and Tissue Engineering research groups of the Department of Biomedical Engineering (www.tue.nl/cb) and the Institute for Complex Molecular Systems (www.tue.nl/icms).
We are looking for enthusiastic candidates who are in an MSc program or who already have an MSc degree, preferably in Biology or Biomedical Engineering. An interest in Synthetic Biology is required. Experience with mammalian cell culture, cloning and generation of stable mammalian cell lines is required.
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