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PhD in mammalian synthetic biology

The Eindhoven University of Technology (TU/e) has the following vacancy: PhD in Mammalian synthetic biology within the department of Biomedical Engineering (BME).

9 maanden geleden


de Rondom, Eindhoven, Noord-Brabant
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur


We are searching for a young scientist who is interested in the programming of new functions into mammalian cells to develop living sensor-actuator devices that can recognize and respond to diverse chemical inputs. The position is part of the NWO-VIDI project NanoSyn. You will learn to reprogram cells to respond to peptide-based stimuli and use this technology to develop a distributed cellular computing platform. The ultimate aim of this project is to develop synthetic mammalian cell devices, each with well-defined computational instructions that execute multicellular logic functions. The project will benefit of international collaborations with groups active in the field of mammalian synthetic biology.

About Eindhoven University of Technology (TU/e):
The TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, with close links to healthcare and industry. The TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

About the Department of Biomedical Engineering (BME):
The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters Biomedical Engineering, Medical Sciences and Technology and Medical Engineering in its Graduate Program. Research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modeling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

About the Institute for Complex Molecular Systems (ICMS):
The Institute for Complex Molecular Systems is an interdisciplinary institute at Eindhoven University of Technology (TU/e) which brings excellent researchers from different areas together to promote crossbreeding of ideas across disciplines in the departments Biomedical Engineering, Applied Physics, Chemical Engineering and Chemistry, Mathematics and Computer Science, and Mechanical Engineering. The institute aims to create and study biologically relevant functional structures with the ultimate goal of understanding the complexity of life.

About Synthetic Biology:
Work in the Synthetic Biology and Molecular Programming group (7 PhD students, 2 post-docs) is directed at the bottom-up construction of basic cellular functions from well-characterized biological components, and the development of novel biological computing devices that can enhance signalprocessing capabilities of natural and synthetic cells. This involves the design and construction of integrated genetic, protein or DNA-based circuits, either in a cell-free environment or in living cells, capable of autonomously performing useful functions. This multidisciplinary approach combines diverse research areas such as DNA/RNA nanotechnology, genetic engineering, and microengineering, guided by computational modeling and simulations of biochemical networks. Ultimately, advances in synthetic biology will allow the development of functional living and hybrid technologies such as biological robots, synthetic cells or augmented natural cells, that can be interfaced with the human body to detect disease biomarkers and allow autonomous, closed-loop therapeutic functions. Laboratories are shared with the Computational Biology, Chemical Biology and Tissue Engineering research groups of the Department of Biomedical Engineering (www.tue.nl/cb) and the Institute for Complex Molecular Systems (www.tue.nl/icms).


We are looking for enthusiastic candidates who are in an MSc program or who already have an MSc degree, preferably in Biology or Biomedical Engineering. An interest in Synthetic Biology is required. Experience with mammalian cell culture, cloning and generation of stable mammalian cell lines is required.


We offer:
  • A challenging job at a dynamic and ambitious University and in an enthusiastic team.
  • An appointment (1 fte) as a PhD-student for four years, starting date: flexible, but preferably as soon as possible.
  • Gross monthly salaries are in accordance with the Collective Labour Agreement of the Dutch Universities (CAO NU), increasing from € 2222 per month initially, to € 2840 in the fourth year.
  • An attractive package of fringe benefits, including excellent work facilities, end of the year allowance and sports facilities.
  • Additionele informatie

    More information:
  • Information about the Biomedical Engineering department can be found via: w3.bmt.tue.nl/en.
  • Other information can be obtained from the HR department, (email: hrservices.gemini@tue.nl)

  • How to apply:
  • If you are interested in this position and would like to apply, we request you to use the button "Apply now". Only applications that are sent via the website will be considered.
  • Your application can be addressed to Dr. Tom de Greef. Applications must include all of the following: (i) a personal motivation letter, (ii) a Curriculum Vitae including the names and contact details of three references, (iii) transcripts of BSc and MSc degrees with all courses and grades, and (iv) a digital copy of BSc and MSc theses (if these are very large, you can send them by email).
  • Only complete applications will be considered. Screening of applicants will start as soon as applications are received and will continue until the position has been filled.