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PhD Single Chain Polymeric Nanoparticles for Fast Prodrug Activation

The Laboratory of Macromolecular and Organic Chemistry at the TU Eindhoven is looking for an Early Stage Researcher (PhD student) to develop his PhD thesis project on the development of a novel bio-orthogonal catalysts based on single chain polymeric nanoparticles.

6 maanden geleden

Arbeidsvoorwaarden

Standplaats:
de Rondom, Eindhoven, Noord-Brabant
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
Opleidingsniveau:
WO

Functieomschrijving

The contract will be within the framework of the Marie Sk³odowska-Curie European Training Network THERACAT, whose objective is to train a new generation of early stage researchers in innovative topic of bio-orthogonal catalysis for cancer therapy. THERACAT is an international and multidisciplinary consortium comprising 6 academic partners from top European institutions, 3 industrial partners active in the pharmaceutical market, and a partner focussing on science communication.

The successful candidate will develop research involving:
- The synthesis of a family of catalytically active amphiphilic polymers that, driven by supramolecular interactions, fold around a transition-metal based centre into compact conformations: single chain polymeric nanoparticles (SCPNs).
- The evaluation of protecting groups that cleave fast in the presence of selected transition metals.
- In vitro screening of appropriate ligands that are stable in biological conditions, show sufficiently strong binding to the metal to prevent leaching, and show high activity in the deprotection reaction.
- In vivo screening of the best performing catalysts.

Functie-eisen

Requirements for Candidates:
- Master degree in Chemistry, Physical Chemistry, Molecular Sciences, or related discipline.
- Solid background in organic synthesis and/or polymer chemistry and a keen interest in catalysis and cell studies.
- Good communication skills, fluency in English (written and oral), and a strong motivation to do original, fundamental research in an interdisciplinary team.
- Self-critical, capacity to learn and bring knowledge.

Marie-Curie Fellowship Mobility Requirement:
At the time of recruitment by the TU/e, the candidate must not have resided or carried out their main activity (work or studies) in The Netherlands for more than 12 months in the 3 years immediately prior to their recruitment.

Arbeidsvoorwaarden

We offer:
-
A challenging job in a dynamic and ambitious, multidisciplinary research team at the Institute for Complex Molecular Systems (ICMS) at Eindhoven University of Technology. Gross monthly salaries € 2222,- to € 2840,- in accordance with the Collective Labor Agreement of the Dutch Universities (CAO NU). Moreover, a 8% bonus share (holiday supplement) is provided annually. We also offer an attractive package of fringe benefits (including excellent work facilities, child care and sport facilities) and we can help you find accommodation.
- The candidate is expected to finish the project with a PhD thesis and disseminate the results through, publications in peer-reviewed journals and presentations at international conferences.

Additionele informatie

Additional Information:
For more information please visit jobs.tue.nl or contact Dr. Ir. ARA Palmans +31 (0)40 247 3105 / a.palmans@tue.nl. Information about terms of employment can be obtained from Linda van den Boomen, HR advisor, email: l.j.c.v.d.boomen@tue.nl.
Further information about Eindhoven University of Technology and the department of Chemical Engineering & Chemistry can be found at www.chem.tue.nl.

Application Procedure:
Please send your application via the apply-now button. To ensure consideration, your application should include the following documents (in PDF format):

- An application letter that outlines your qualification, interest and motivation for this position
- A CV with details on education, employment, publications, and research experience, as well as contact information for two referees.

Please send your application documents before 15-07-2018. Review of applications will start as soon as applications are received and will continue until the position has been filled.

Selected References:
- Liu Y et al, Catalytically Active Single-Chain Polymeric Nanoparticles: Exploring Their Functions in Complex Biological Media. J. Am. Chem. Soc. 2018, 140, 3423-3433 (DOI: 10.1021/jacs.8b00122).