Ongeveer 13 uur geleden - Technische Universiteit Delft (TUD) - Delft
We are looking for talented individuals with a strong background and track-record in chemical engineering who strive to bring innovations in the field. We …
The Laboratory of Macromolecular and Organic Chemistry at the TU Eindhoven is looking for an Early Stage Researcher (PhD student) to develop his PhD thesis project on the development of a novel bio-orthogonal catalysts based on single chain polymeric nanoparticles.
The contract will be within the framework of the Marie Sk³odowska-Curie European Training Network THERACAT, whose objective is to train a new generation of early stage researchers in innovative topic of bio-orthogonal catalysis for cancer therapy. THERACAT is an international and multidisciplinary consortium comprising 6 academic partners from top European institutions, 3 industrial partners active in the pharmaceutical market, and a partner focussing on science communication.
The successful candidate will develop research involving:
- The synthesis of a family of catalytically active amphiphilic polymers that, driven by supramolecular interactions, fold around a transition-metal based centre into compact conformations: single chain polymeric nanoparticles (SCPNs).
- The evaluation of protecting groups that cleave fast in the presence of selected transition metals.
- In vitro screening of appropriate ligands that are stable in biological conditions, show sufficiently strong binding to the metal to prevent leaching, and show high activity in the deprotection reaction.
- In vivo screening of the best performing catalysts.
Requirements for Candidates:
- Master degree in Chemistry, Physical Chemistry, Molecular Sciences, or related discipline.
- Solid background in organic synthesis and/or polymer chemistry and a keen interest in catalysis and cell studies.
- Good communication skills, fluency in English (written and oral), and a strong motivation to do original, fundamental research in an interdisciplinary team.
- Self-critical, capacity to learn and bring knowledge.
Marie-Curie Fellowship Mobility Requirement:
At the time of recruitment by the TU/e, the candidate must not have resided or carried out their main activity (work or studies) in The Netherlands for more than 12 months in the 3 years immediately prior to their recruitment.
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