During this project you will develop and exploit an experimental setup able to measure the spatial diffusion of photo-excited electron-hole pairs (excitons) …
PhD student Biosensors for point-of-care diagnostics
The Eindhoven University of Technology (TU/e) has the following vacancy:
PhD candidate Biosensors for point-of-care diagnostics.
- Eindhoven, Noord-Brabant
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 38 uur
Point-of-care diagnostics enable the transfer of traditionally laboratory-based diagnostic procedures away from the laboratory to the patient's bedside or home. The Merkx group recently developed a new platform of bioluminescent sensor proteins (LUMABS; LUMinescent AntiBody Sensor) for antibody detection that allow detection of biomarkers directly in blood plasma using the camera of a smart phone as the sole piece of equipment (Arts et al (2016) Anal. Chem. Vol 88, 4525-4531). Supported by a RAAK grant that promotes translational research (Printing makes sense), this novel sensor technology will be further developed into devices for various point-of-care applications by a consortium consisting of the Fontys university of applied sciences, the TU Eindhoven, a hospital and a number of companies. The main aim of this project is to develop cheap and easy to use microfluidic devices for point-of-care diagnostics using advanced printing technologies. The PhD student will be responsible for developing new bioluminescent sensor protein formats and optimizing those for specific biomedical applications. In addition, the PhD student will be involved in the development of microfluidic devices specific for ratiometric bioluminescent detection assays. The PhD student will also support research by the other partners in the consortium, both by providing biochemical expertise and protein reagents. The position provides a unique opportunity to work at the forefront of biosensor engineering and develop a broad expertise in point-of-care diagnostics.
The PhD student will be embedded in the protein engineering group headed by prof.dr. Maarten Merkx, Biomedical Engineering, in close collaboration with the microsystems group headed by prof.dr.ir Jaap den Toonder, Mechanical Engineering. Both research groups are part of the Institute of Complex Molecular Systems (ICMS), which also supports this project. The protein engineering group is has modern facilities for molecular biology, protein expression and purification, organic synthesis, fluorescence microscopy and cell biology. The microsystems group manages the Microfab lab, a state-of-the-art micro fabrication facility that houses a range of micro manufacturing technologies. Access to range of other technologies and expertise in printing, surface functionalization and clinical validation is available through other partners in the RAAK consortium.
We are looking for a molecular scientist who enjoys to work in a multidisciplinary academic environment and translate his/her knowledge towards point-of-care diagnostic applications. The ideal candidate would have experience in both protein chemistry/engineering and microfluidics, but excellent candidates with a background in one area (and an interest to master the other) will also be considered. Important personal skills include a proven ability to manage projects, collaborate with external parties and be self-driven.
ArbeidsvoorwaardenWe offer you:
Additionele informatieFurther information can be obtained by: prof.dr. M. Merkx, phone +31 40 247 4728 and e-mail email@example.com .
For more information on ICMS, please visit: https://www.tue.nl/en/research/research-institutes/top-research-groups/institute-for-complex-molecular-systems/
Your application can be addressed to prof.dr. M. Merkx. Applications must include a personal motivation letter, a Curriculum Vitae including the names and contact details of at least two references, and an overview of current research activities and interests (1-2 pages). Only complete applications will be considered. Consideration of the candidates will begin immediately, until the position is filled.
If you would like to apply, please send us your application by using the 'apply now' button on the TU/e website.