PostDoc – Computational and experimental remodeling of heart valves
Are you eager to work on preserving and regenerating heart valve function under non-physiological loading conditions?
- de Rondom, Eindhoven, Noord-Brabant
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 38 uur
This vacancy is posted as part of RegMedXB, which stands for 'Regenerative Medicine Crossing Borders'. RegMedXB is a virtual institute composed of universities, health foundations, governments and private companies in the Netherlands and Belgium. The partners work together to tackle some of the greatest challenges in regenerative medicine, while building a community of researchers and companies to realize health and economic benefits. The RegMedXB Cardiac Moonshot program aims at developing innovative strategies to regenerate the tissues of the heart, including the myocardium, heart valves and blood vessels.
The current project concentrates on preserving and regenerating heart valve function under non-physiological loading conditions. For this you will investigate the structural and biological remodeling of heart valves using a combination of experimental and computational research.
The experimental research will focus on establishing an ex vivo platform to investigate the remodeling and functionality of heart valves under various hemodynamic conditions.
The computational part focuses on simulating valve remodeling, with the aim of understanding and predicting experimental outcomes, and extrapolating findings to relevant in vivo situations.
If you are fascinated by the engineering aspects of regenerative medicine and eager to develop innovate models and strategies that will advance cardiovascular regeneration, we invite you to join us in this challenge. You will collaborate intensively with our partners in the RegMed-XB Cardiac Moonshot consortium, in particular with the University Medical Centers in Leiden and Utrecht on ex vivo tissue remodeling, and with other TU/e groups on computational modeling and tissue engineering.
- A PhD degree in biomedical engineering, mechanical engineering, regenerative medicine,
or a comparable domain
- Ability to conduct high quality academic research, demonstrated for instance by relevant publications in the area of research
- Background in mechanobiology and affinity with medical applications
- Profound knowledge of and experience with computational biomechanics
- Experience with tissue culture and tissue characterization
- Be a team player and able to contribute to and initiate cross-disciplinary collaborations
- Excellent mastering of the English language, good written and oral communication skills. Note that there is no Dutch language requirement.
- Result-driven and proactive attitude
- A meaningful job in a dynamic and ambitious university with the possibility to present your work at international conferences.
- A full-time employment for 2 years, starting with a one-year contract.
- You will have free access to high-quality training programs for research and valorization, professional development courses for PhD students, and didactical courses of the TEACH training program.
- A gross monthly salary and benefits in accordance with the Collective Labor Agreement for Dutch Universities.
- A broad package of fringe benefits (including an excellent technical infrastructure, moving expenses, and savings schemes).
- Family-friendly initiatives are in place, such as an international spouse program, and excellent on-campus children day care and sports facilities.
Additional informationMore information
Information about the RegMedXB program can be found on: www.regmedxb.com
Information about the Biomedical Engineering department can be found at: https://www.tue.nl/en/university/departments/biomedical-engineering/
Information about the Soft Tissue Engineering & Mechanobiology group can be found on: www.tue.nl/STEM
Do you recognize yourself in this profile and would you like to know more? Please contact:
- prof.dr. C.V.C. Bouten (c.v.c.bouten[at]tue.nl),
- dr.ir. S. Loerakker (s.loerakker[at]tue.nl) or
- dr.ir. A.I.P.M. Smits (a.i.p.m.smits[at]tue.nl).
For information about terms of employment, click here or contact Sascha Sanchez, HR advisor, s.j.m.g.sanchez.van.oort[at]tue.nl or HRServices.Gemini[at]tue.nl
Please visit www.tue.nl/jobs to find out more about working at TU/e!
We invite you to submit a complete application by using the 'apply now'-button on this page.
The application should include a:
- Cover letter in which you describe your motivation and qualifications for the position.
- Curriculum vitae, including a list of your publications and the contact information of
- List of five self-selected 'best publications'.
We look forward to your application and will screen it as soon as we have received it. Screening will continue until the position has been filled. We do not respond to applications that are sent to us in a different way. Please keep in mind you can upload only 5 documents up to 2 MB each.
If necessary please combine files.
About Eindhoven University of Technology (TU/e)
TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.
The Department of Biomedical Engineering (BME) offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.
The research will be mainly conducted within the Soft Tissue Engineering and Mechanobiology (STEM) group in the Department of Biomedical Engineering.
The STEM group, headed by prof.dr. C.V.C. Bouten, concentrates on the engineering of soft tissues, aimed at either the replacement of diseased or malformed tissues, or the development of in-vitro model systems of developing tissues. Important fundamental research lines concern the biophysical (stem) cell niche and the mechanobiology of tissue organization. Results are used to design novel approaches of in-situ tissue regeneration, with principle application in the cardiovascular area (heart valves and vessels) and organ regeneration (heart, kidney). The group houses the Cell and Tissue Engineering laboratory, a shared research infrastructure operating at the international forefront of the engineering of living, load-bearing tissues.
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