Postdoc On-chip kidney interaction model

The Eindhoven University of Technology (TU/e) has the following vacancy:
Postdoctoral researcher – On-chip kidney interaction model.

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Arbeidsvoorwaarden

Standplaats:
Eindhoven, Noord-Brabant
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

About TU/e:

TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

About BME:

The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

About the BME Soft Tissue Engineering and Mechanobiology group

The STEM group (www.tue.nl/stem), headed by prof.dr. C.V.C. Bouten, concentrates on the engineering of soft tissues, aimed at either the replacement of diseased or malformed tissues, or the development of in-vitro model systems of developing tissues. Important fundamental research lines concern the biophysical (stem) cell niche and the mechanobiology of tissue organization. Results are used to design novel approaches of in-situ tissue regeneration, with principle application in the cardiovascular area (heart valves and vessels) and organ regeneration (heart, kidney). The group houses the Cell and Tissue Engineering laboratory, a shared research infrastructure operating at the international forefront of the engineering of living, load-bearing tissues.

Importantly, this position will be partly seconded to the department of Mechanical Engineering and much of the research will be supervised by Prof.dr.ir. J.M.J. den Toonder.

About ME:

The Mechanical Engineering Department focuses on research in the field of product and process design and manufacturing. The crux of the department is devoted to designing, analyzing, improving and manufacturing new products and processes, as well as the materials needed for this. The Department's research areas range from materials & mechanics, to energy & flow, to dynamics & control. The department is a breeding ground for international top-level research, with much collaboration with industry. The department has more than 1100 (BSc and MSc) students and 250 employees of whom more than 100 are PhD candidates and postdoctoral researchers.

About the ME Microsystems group:

The Microsystems group (www.tue.nl/microsystems), headed by prof.dr.ir. J.M.J. den Toonder, develops microsystems design approaches and out-of-cleanroom micro-manufacturing technologies that are rapid and flexible. These are applied to realize active mechanical control in micro-fluidics, to make and study meso-structured and soft materials, to create biomedical microdevices to study cells and organs on chips, and to develop advanced micromechanical actuators and sensors for various microsystems applications, often in collaboration with industrial partners. The group has a micro-fabrication lab that forms the basis of much of the research and education in the group: the Microfab/lab.

About RegMedXB:

This vacancy is posted as part of RegMedXB, which stands for 'Regenerative Medicine Crossing Borders'. RegMedXB is a virtual institute composed of universities, health foundations, governments and private companies in the Netherlands and Belgium. The partners work together to tackle some of the greatest challenges in regenerative medicine, while building a community of researchers and companies to realize health and economic benefits. For more information, please visit www.regmedxb.com.

Job description

The adult kidney is a highly complex organ, containing more than twenty highly specialized cell types, arranged in a spatial architecture critical to its function. The human kidney is composed of approximately one million functional units, the nephrons that filter and remove excess material and waste products from the blood, and take care of metabolic, hemodynamic and endocrine functions. Worldwide, the number of patients with end-stage kidney disease necessitating dialysis or transplantation is reaching epidemic proportions. Kidney transplantation currently offers the best treatment option but is associated with limited transplant availability and rejection. Within the RegMed XB Kidney Moonshot program, the overall aim is to develop innovative strategies to regenerate kidneys and to provide renal replacement therapies.

The project of this position aims to develop a microfluidics-based model that forms a minimal representation of kidney function and which can be used to get insight into processes relevant for kidney regeneration. The model will follow a development towards integrating more complexity if needed to realize kidney function. The postdoctoral researcher will design and fabricate the microfluidic device, establish a cell co-culture within the device representative of the basic nephron function, and characterize the obtained in-vitro model e.g. characterizing morphology, active transport, and using biological readouts.

We will strongly collaborate with all partners in the RegMed-XB Kidney Moonshot consortium, in particular with UMCU and LUMC on cell sources and readouts, with MERLN on modeling and integration of complex geometry, and with MERLN and TU/e on synthetic matrices.

Functie-eisen

We are accepting applications from enthusiastic candidates who are interested in a dynamic, stimulating and ambitious environment to perform their research. The candidate should have a PhD in biomedical engineering, mechanical engineering, or an equivalent area, and have background in micro-fabrication and biology, and should have affinity with (bio) medical applications. Experience with microfluidic device manufacturing and cell culture is highly appreciated. The candidate will be able to effectively communicate scientific ideas, foster collaboration and have a capability for independent thinking. Moreover, the candidate should be able to work independently within a dynamic team and be skilled in written and spoken English.

Arbeidsvoorwaarden

We offer you:
  • An exciting job in a dynamic work environment.
  • A fulltime appointment for three years at Eindhoven University of Technology (www.tue.nl/en).
  • The salary is in accordance with the Collective Labor Agreement of the Dutch Universities (scale 10), depending on your experience.
  • The possibility to present your work at international conferences.
  • An attractive package of fringe benefits, including end-of-year bonus (8,3% in December), an extra holiday allowance (8% in May), moving expenses and excellent sports facilities.
  • Additionele informatie

    Information about the RegMedXB program can be found on: www.regmedxb.com

    Information about the Biomedical Engineering and Mechanical Engineering department can be found on: https://www.tue.nl/en/university/departments/biomedical-engineering/ and https://www.tue.nl/en/university/departments/mechanical-engineering/

    Information about the Soft Tissue Engineering & Mechanobiology and Microsystems groups can be found on: www.tue.nl/STEM and https://www.tue.nl/microsystems

    Questions regarding the academic content of the position can be directed to prof.dr. C.V.C. Bouten (c.v.c.bouten@tue.nl) and prof.dr.ir. J.M.J. den Toonder (j.m.j.d.toonder@tue.nl).

    Other information can be obtained from the HR department, email: HRServices.Gemini@tue.nl

    If you would like to apply, please send us your application by using the 'apply now' button on the TU/e website.

    Your application should be addressed to prof.dr. C.V.C. Bouten and prof.dr.ir. J.M.J. den Toonder. Your application must include: a one-page personal motivation letter, a CV including the names and contact details of two recent references. Only complete applications will be considered.

    Screening of applicants will start as soon as applications are received and will continue until the position has been filled.

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