Ongeveer 17 uur geleden - Universiteit van Amsterdam (UvA) - Amsterdam
The Amsterdam School for Cultural Analysis, one of six research schools of the Faculty of Humanities, has a vacant PhD position as part of the ERC …
We are looking for a Postdoc on Modelling of a biosensor for continuous monitoring with single-molecule resolution.
The group Molecular Biosensing for Medical Diagnostics (MBx, see www.tue.nl/mbx) at Eindhoven University of Technology (TU/e) creates ideas and generates scientific insights in the area of molecular biosensing with single-molecule resolution. This involves the engineering of molecular constructs for sensing applications (using protein, nucleic-acid, and protein-DNA technologies), methods to biofunctionalize nanoparticles, the development of novel single-molecule measurement methods, optical microscopies, particle characterization techniques, plasmonic effects, particle actuation principles, signal processing, and simulations. The research leads to novel methods for molecular biosensing, insights into protein function within complex and crowded environments, and novel routes into point-of-care and patient monitoring applications. The MBx group initiated and organizes SensUs, the international competition on Sensors for Health (www.sensus.org). Laboratories are shared with the Chemical Biology research group (www.tue.nl/cb) and the Institute for Complex Molecular Systems (www.tue.nl/icms).
The group Theory of Polymers and Soft Matter group (TPS, see www.tue.nl/tps) in the department of Applied Physics at TU/e focuses on the multiscale physics of biological and synthetic organic matter. From protein to organ, from polymer chain to plastic, and employs a variety of analytical and computational theoretical-physical methods - ranging from statistical and soft-matter physics to large-scale computer simulations - to help deepen the understanding of the complex interplay between biomolecular structure, function and dynamics. The group is part of the Institute for Complex Molecular Systems (www.tue.nl/icms).
The Institute for Complex Molecular Systems (www.tue.nl/icms) is an interdisciplinary institute at TU/e which brings excellent researchers from different areas together to promote cross-breeding of ideas across disciplines in the departments Biomedical Engineering, Applied Physics, Chemical Engineering and Chemistry, Mathematics and Computer Science, and Mechanical Engineering. The institute aims to create and study biologically relevant systems with the ultimate goal of understanding the complexity of life.
The postdoc project focuses on developing and validating predictive models for a new biosensing technology with single molecule resolution. The technology is based on the tracking of the motion of particles that are molecularly tethered to a substrate, where modulations of the motion indicate the presence of single biomarker molecules. You will address questions on sensor design (e.g. role of molecular affinity, tether design, molecular densities), sensing kinetics, sensitivity, detection range, reversibility, scaling with number of particles, data analysis methods, etc. The questions will be addressed using thermodynamic models, Monte Carlo simulations, Brownian Dynamics simulations, and Molecular Dynamics simulations. The models will be validated using experimental and simulated data, generated by you and other members of the project. The project will give detailed insights in the mechanisms underlying the sensing technology and will yield design rules for molecular constructs, analysis protocols and system engineering. The postdoc position is part of a collaboration between the MBx group, the TPS group, the Chemical Biology and Protein Engineering group, Leiden University Medical Center, and three companies: Medtronic, Future Diagnostics, and Anteryon.
We are looking for enthusiastic candidates who are in an PhD program or who already have a PhD degree, preferably in Physics or Chemistry. Experience with computational modelling and an interest in Physical Chemistry and Biophysics is required. Experience with single-molecule methods (theory and experiment) is a plus.