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Postdoc position Protein Nanocarriers for Anticancer Therapy

The Eindhoven University of Technology (TU/e) has the following vacancy:
A postdoctoral position protein nanocarriers for anticancer therapy is available for the development of temperature]responsive polypeptide nanocarriers for controlled drug delivery to metastasized ovarian cancer. The function is part of the European project TEMPEAT. The nanocarrier systems will be made and tested in close collaboration between TU/e and the Radboudumc.

4 maanden geleden

Arbeidsvoorwaarden

Standplaats:
de Rondom, Eindhoven, Noord-Brabant
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

About Eindhoven University of Technology (TU/e):

The TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. The TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

About the Department of Biomedical Engineering (BME):

The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters Biomedical Engineering, Medical Sciences and Technology and Medical Engineering in its Graduate Program. Research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modeling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

About the group:

The research of the Bio-organic chemistry group is aimed at the development of smart nanosized compartments. These compartments are used in nanomedicine as vehicles in drug delivery and as scaffolds in immunology. Furthermore, they are employed as nanoreactors, with application potential in artificial cell and organelle research. The nanomedicine research line in particular concerns medicine transport systems and synthetic vaccines. Using a combination of techniques from polymer science to protein engineering, well-defined carriers and scaffolds are developed for application in e.g. cancer treatment, immunology and ophthalmology.

About the Radboudumc/RIMLS:

The Radboudumc is one of the University Medical Centers of the Netherlands with a mission to have a significant impact on health care. The Radboud Institute for Molecular Life Sciences (RIMLS) at the Radboudumc conducts research on the molecular basis of health and disease with the aim to develop new diagnostics and therapies. Nanomedicine and Women's cancers are two of the research themes of the Radboudumc. The Radboudumc provides excellent research facilities among which the microscopy imaging center with a panel of advanced microscopy techniques, the PRIME for preclinical imaging, and facilities for animal experimentation.

About the Departments of Biochemistry and Gynecology:

The department of Biochemistry is one of the preclinical departments of the Radboudumc with research in targeted drug delivery, regenerative medicine and tissue engineering, and mitochondrial dynamics and metabolism. Fundamental research is conducted in close collaboration with clinical groups to promote a translation of fundamental insights into potential clinical applications. TEMPEAT builds on projects using protein engineering of nanobodies to target cancer and intracellular delivery of nanoparticles using cell-penetrating peptides.

The Dept. of Biochemistry has a long-standing collaboration with the Dept. of Gynecology and in particular Gynecological Oncology which provides patient care in this field but also strives to develop novel treatment regimes with the aim to improve the survival and quality of life of the patients.

Job Description:

A postdoctoral position is available for the development of temperature]responsive polypeptide nanocarriers for controlled drug delivery to metastasized ovarian cancer. The function is part of the European project TEMPEAT. The nanocarrier systems will be made and tested in close collaboration between TU/e and the Radboudumc. Activities include the synthesis and characterization of nanoparticles, their functionalization, optimization and functional characterization, in vitro and in vivo. The techniques range from protein expression and purification to the characterization of nanoparticles using physicochemical techniques, cellular uptake and activity to in vivo testing in murine ovarian cancer models. The research tasks are closely embedded in ongoing research activities of the participating departments. As a post-doc you will be responsible for the overall organization of the project at TU/e and RIMLS, and it is expected that you will be working at both sites.

Functie-eisen

We seek a highly talented, enthusiastic, and exceptionally motivated postdoc candidate with experience in at least two of the following fields: Protein engineering, nanomedicine, cell biology, advanced microscopy. Experience with animal experimentation (level 9 course) is strongly desired. At the beginning, the focus of the activities will be in Eindhoven, with a gradual shift to Nijmegen at the Depts. of Gynecology and Biochemistry.

The candidate must have strong communication and organizational skills. Fluency in written and spoken English is obligatory. The candidate should be able to work in a team and be willing to function in two institutes.

Arbeidsvoorwaarden

We offer you:
  • A challenging job interfacing the research group of bio-organic chemistry, TU/e, Eindhoven, and the department of Biochemistry, of the Radboud University Medical Center, both in The Netherlands
  • A full time split appointment by Eindhoven University of Technology (50%) and Radboudumc (50%) for a period of 1 year. After a good evaluation your contract can be extended with an additional period of max. 2 years.
  • The gross monthly salary (scale 10) depends on your experience and is in accordance with the Collective Labor Agreement of the Dutch Universities (TU/e) and Collective Labor Agreement University Medical Centre (Radboud UMC).
  • An attractive package of fringe benefits, including excellent work facilities, childcare, moving expenses, sports facilities, an extra holiday allowance (8%, May), and an end-of-year bonus (8.3%, December).
  • Additionele informatie

    For more information you can contact:

    - TU/e: Prof.dr.ir. Jan van Hest, email: J.C.M.v.Hest@tue.nl

    - Radboud UMC: Prof.dr. Roland Brock, email: Roland.Brock@radboudumc.nl and Dr. William Leenders, email: William.Leenders@radboudumc.nl

    Other information can be obtained from Mrs. Lonneke van Luxemburg, HR advisor at TU/e, email: L.a.m.v.Luxemburg@tue.nl

    If you are interested in the post-doc position, and would like to apply, please send us your application by using the 'apply now' button on the website.

    Your application should be addressed to Prof.dr.ir. Jan van Hest, Prof.dr. Roland Brock and Dr. William Leenders. Your application must include: a one-page personal motivation letter, a digital copy of your PhD thesis, a CV including the names and contact details of two recent references. Only complete applications will be considered.

    Screening of applicants will start as soon as applications are received and will continue until the positions have been filled.