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The Eindhoven University of Technology (TU/e) has the following vacancy:
postdoctoral Fellow position in Hydrogel Development for Osteochondral Implants.
TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.
The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.
About the BME Orthopaedic Biomechanics group:
This group combines the disciplines of engineering and biology to increase our knowledge of the adaptive, developmental and physiological nature of musculoskeletal tissues. This knowledge is then applied to explore and develop regenerative treatment strategies, currently applied to bone, articular cartilage, intervertebral disc and tendons/ligaments. The group consists of multi-disciplinary scientists and engineers at all levels employing numerical and experimental as well as engineering, imaging, biological and chemical techniques.
Importantly, this position will be seconded to the Department of Pharmaceutical Sciences at Utrecht University, and much of the research will be supervised by Dr. T. Vermonden.
Utrecht University has great ambitions for its teaching quality and study success rates. This also applies to its clear research profiles which are centered around four themes: Sustainability, Life Sciences, Youth & Identity, and Institutions. Utrecht University plays a prominent role in our society and contributes to finding the answers to topical and future societal issues.
The Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty's academic programmes reflect developments in today's society.
About the UU Pharmaceutics group:
The core activity of the Pharmaceutics groups (www.uu.nl/pharmaceutics) is the design and pre-clinical testing of tailor-made drug delivery systems for site-specific, time- and/or rate-controlled delivery of small molecular weight drugs, therapeutic proteins, and nucleic acids (including DNA and siRNA). The major strength of the department is the multidisciplinary nature. As such it can cover the development of biomaterials and drug delivery systems from the design and synthesis up to preclinical testing. It has a good infrastructure for synthesis and characterization of biomaterials and nanoparticles in addition to a dedicated cell culture facility. The dept. Pharmaceutics is a member of the faculty of Science, but is also part of the Utrecht Life Science Cluster with the aim to advance therapies into the clinic. In addition, the dept. Pharmaceutics has many collaborations with academic groups and biopharmaceutical companies worldwide.
About RegMedXB and InSciTe:
This vacancy is posted as part of RegMedXB, which stands for 'Regenerative Medicine Crossing Borders'. RegMedXB is a virtual institute composed of universities, health foundations, governments and private companies in the Netherlands and Belgium. The partners work together to tackle some of the greatest challenges in regenerative medicine, while building a community of researchers and companies to realize health and economic benefits. For more information, please visit www.regmedxb.com.
This position is also part of the Chemelot Institute for Science & Technology (InSciTe), a public-private institute for developing smart healing biomedical materials for high quality, affordable healthcare. With its physical nucleus at Brightlands Chemelot Campus, it enables entrepreneurship, expertise, experimentation and education in an open innovation network. In this project, the founding partners, TU/e and DSM, will work together with other RegMedXB partners to achieve their phase-1 aim of bringing a functional regenerative osteochondral implant to first-in-man trials.
The project of this position concerns the development of a swelling hydrogel that will be an essential part of an osteochondral implant. The implants consist of a cartilage part and an osteoconductive base, which will be developed in parallel before they are integrated. The cartilage approach uses a so-called 'hydrospacer', which is a spacer fabric that is filled with a swelling hydrogel. The swelling hydrogel and the fiber will together be responsible for the load-bearing properties. This project focusses on the fabrication of polysaccharide based hydrogels with different swelling properties including investigating their mechanical properties and cytocompatibility.
We are accepting applications from enthusiastic candidates who are interested in a dynamic, stimulating and ambitious environment to perform their research. The candidate must have a PhD degree in organic/polymer chemistry, biomaterials, drug delivery, tissue engineering, or equivalent.
Candidates are expected to have experience with organic/polymer synthesis and characterization techniques. Experience with hydrogel preparation and characterization is highly appreciated. The candidate will be able to effectively communicate scientific ideas, foster collaboration and have a capability for independent thinking. Moreover, the candidate should be able to work independently within a dynamic team and be skilled in written and spoken English.