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  3. PhD in Medical Systems Biology: Translational models for peroxisomal dysfunction

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PhD in Medical Systems Biology: Translational models for peroxisomal dysfunction

Project description In this ‘Systems Medicine’ project we will focus on the construction of computational models to understand how severe acute malnutrition …

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Arbeidsvoorwaarden

Standplaats:
Hanzeplein, Groningen, Groningen
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Opleidingsniveau:
WO

Functieomschrijving

Project description
In this ‘Systems Medicine’ project we will focus on the construction of computational models to understand how severe acute malnutrition (SAM) leads to sustained dysfunction of peroxisomal and mitochondrial metabolism. A challenge for such an approach is to bridge the gap between computational models and the in vivo metabolism in patient tissues. To this end the PhD student will also develop in vitro disease models, such as liver organoids and iPS-derived liver cell culture. Tasks include:
- Establish an in vitro model for SAM (liver iPS cells and/or organoids in medium deprived of amino acids).
- Biochemical characterization of the in vitro malnutrition model, focusing on fluxomics and proteomics.
- Construct a computational model of the interplay between peroxisomes and mitochondria in lipid metabolism.
- Model-informed interventions to rescue peroxisomal-mitochondrial function.

Functie-eisen

We are searching for an excellent, highly motivated candidate with a masters’ degree in life sciences, biophysics, biochemistry, or a related field, and clear affinity for metabolism and mathematics. Candidates are expected to communicate efficiently in an interdisciplinary team of academic and private partners, consisting of biochemists, biologists, and computational experts.

Successful candidates must fulfil the criteria defined by the European Commission:
- As an Early Stage Researcher, you have to be in the first four years of your research career and have not been awarded a doctoral degree at the time of recruitment.
- At the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the reference date.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

Conditions

An appointment as a PhD student for three years. Your salary is € 2.357,- gross per month in the first year up to a maximum of € 3.020,- gross per month in the third year (scale PhD) depending on qualifications. In addition, the UMCG will offer you 8% holiday pay and 8.3% end-of-year bonus. The terms of employment comply with the Collective Labour Agreement for Medical Centers (CAO-UMC).

Additional information
For more information, please contact Prof. Barbara Bakker, e-mail: b.m.bakker01@umcg.nl or phone + 31 50 361 1542 ( (please do not use e-mail adress for applications)

Applying for the job
Please use the the digital application form at the bottom of this page - only these will be processed.
You can apply until 24 February 2019.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.

Applications should include a motivation letter and a curriculum vitae including two contacts for reference.

Additional information

the European training programme PerICo

UMCG Corporate information/research

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