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PhD position: Ex vivo perfusion, multi-omics and magnetic resonance imaging of d

Transplant centers worldwide are increasingly utilizing ex vivo normothermic (37°C) machine perfusion to better preserve, evaluate and potentially even repair …

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Arbeidsvoorwaarden

Standplaats:
Hanzeplein, Groningen, Groningen
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Salarisindicatie:
€ 2495 - € 2495 per maand
Opleidingsniveau:
WO

Functieomschrijving

Transplant centers worldwide are increasingly utilizing ex vivo normothermic (37°C) machine perfusion to better preserve, evaluate and potentially even repair damaged donor kidneys prior to transplantation. However, in depth understanding of ex vivo organ physiology is lacking, which seriously impairs our ability to reliably evaluate organ quality during perfusion. In addition, it remains uncertain to what extent normothermic perfusion strategies conserve organ quality better than standard cold preservation techniques. In the EU-funded PRE-IMAGE project, we will focus on these important questions, by combining multi-omics with functional magnetic resonance imaging (fMRI) during ex vivo normothermic kidney perfusion.

Your PhD research will be embedded in the framework of the PRE-IMAGE collaboration. In your PhD project, you will have the opportunity to further explore ex vivo kidney perfusion techniques as well as renal fMRI, both from a technical/engineering and from a biological point of view. You will be actively involved in multicenter experimental and clinical studies that characterize ex vivo renal physiology, as well as determine the diagnostic and biological advantage of normothermic ex vivo kidney perfusion prior to transplantation. Thus, your research will be an important contribution to better understanding how deceased donor kidneys should be assessed, in order to transplant more good organs.

Specifically, together with our current team of PhD students and technicians, you will:
- set up and conduct an extensive series of experimental (porcine) kidney perfusions in an MRI scanner, where you will study in and ex vivo renal physiology side-by-side, by means of multi-omics and advanced functional imaging sequences;
- set up and conduct a large multicenter clinical study in which human kidneys will, for the first time ever, undergo several hours of normothermic ex vivo perfusion prior to actual transplantation.

Please visit the website for more in-depth information.

Last but not least, you will be encouraged to train as a clinical organ perfusionist and participate as team member at the UMCG’s Organ Perfusion and Resuscitation facility, perfusing human donor kidneys, livers and lungs prior to transplantation. This experience may eventually result in a clinical position which extends beyond the boundaries of your PhD.

We envision your PhD project to start early 2021.

Functie-eisen

MSc in Technical Medicine, Biomedical Technology, Medicine, or Biomedical Sciences. You should be a genuine team player, highly motivated, self-driven and willing to also work in a flexible time schedule, including occasional evenings, nights and weekends. In addition, we expect you to have a high level of written and spoken academic English. Being proficient in Dutch is not a prerequisite but will be considered an asset.

You are expected to independently conduct a 3-year research project embedded in the Experimental Transplantation group of Prof. Henri Leuvenink and Dr. Cyril Moers, as well as to collaborate with transplant clinicians at the departments of Surgery and Nephrology of the UMCG. Since part of the PRE-IMAGE project will be conducted at the well-equipped MRI and animal facilities of Aarhus University Hospital in Denmark, a 3-12 month stay abroad could also be part of your project.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

Conditions

- A research project aimed at impact at the highest international level.
- Mentoring, supervision and training in an informal and friendly work climate.
- A fun, stimulating and international research environment.
- Access to state-of-the-art infrastructure.
- The unique opportunity to also become one of our clinical organ perfusionists.

Your salary will be a minimum of € 2.495,- gross per month in the first year and a maximum of € 3.050,- (scale PhD) in the third year, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus.
The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC). English: http://www.nfu.nl/english/about-the-nfu/

More information
Please feel free to contact Dr. Cyril Moers, transplant surgeon and tenure track assistant professor, for more information about this position. E-mail address: c.moers@umcg.nl, phonenumber: +31 50 361 0474 (please do not use this e-mail address for applications).

Information about the Groningen Institute for Organ Transplantation.
Information about Groningen.