Ongeveer 6 uur geleden - Universiteit van Amsterdam (UvA) - Amsterdam
PhD-student (ESR3): Targeted modulation of the adenosine checkpoint
Development of Adenosine-2A-Receptor (A2AR)-targeting bispecific antibodies and preclinical validation tools This challenging PhD opportunity offers an …
- Hanzeplein, Groningen, Groningen
- Tijdelijk contract / Tijdelijke opdracht
FunctieomschrijvingDevelopment of Adenosine-2A-Receptor (A2AR)-targeting bispecific antibodies and preclinical validation tools
This challenging PhD opportunity offers an exciting and innovative research project at the intersection of biotechnology and physical chemistry that will end in a PhD thesis. In brief, a novel bispecific antibody-based approach that removes an important checkpoint on anticancer T cell immunity, namely inhibition by A2AR signaling, will be developed. This approach will be tested in several in-house developed model systems, including microparticles with tumor surface properties, for tumor-selective binding and for functional immunomodulatory activity. This research project will end with a PhD thesis defense at the University of Groningen.
Keywords: Bioanalysis, microparticles, nanoparticles, surface modification, drug-delivery, bispecific antibodies
- Preparation of tumour-targeted bsAbs and nanoparticle-based drug-delivery formulations
- Analysis of biomolecular interactions between model tumor cells and drug-delivery vesicles (nanoparticles loaded with T-cell targeting immunocytokines/bispecific antibodies)
- Development of model tumor cells by means of microparticle synthesis, coating and bio-functionalization
- Various encapsulation and surface modification activities
- Operation, optimization and further development of a bioanalysis platform that uses functionalized microparticles (model tumor cells) as sensors (Measurement principle: Whispering Gallery Modes)
- Optimization of the in vitro test conditions for a realistic simulation of the in vivo conditions
- Management, presentation and publication of research data
- You are in the first four years of your research career and does not have a doctoral degree
- Residence duration in Germany does not exceed 12 months in total within the last 3 years
- MSc in chemistry, biochemistry, biotechnology, engineering or related
- Proven track record in one or more of the following fields:
Absorption and fluorescence spectroscopy
Analysis of biomolecular interactions e.g. protein-protein, antibody-antigen
Biosensors and bioanalysis (Surface Plasmon Resonance, Quartz Crystal Microbalance, Whispering Gallery Modes)
Confocal Laser Scanning Microscopy, Flow Cytometry
Surface modification and functionalization, nanoscale coatings
Nanoparticle / microparticle synthesis
- Affinity to data management and IT
- Collaboration skills, demonstrating agility and initiative. Ability to communicate effectively in English, both internally in the team as well as with consortium partners
- German language or the willingness to learn German is advantageous
The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.
ConditionsA PhD student position for 3 years as part of a Marie Curie Actions Innovative Industrial Doctorate training network. 1st Hosting institution: Location: Surflay, Berlin, Germany, duration: 18 months. 2nd Hosting institution: Location: UMCG, Groningen, Netherlands, duration: 18 months. Intended start date: September 2019. Benefits according to EU MCA regulations.
Applying for a job
Please send your application to firstname.lastname@example.org as job application ESR3 Targeted modulation of the adenosine checkpoint. The application deadline is 31 July 2019.
(please do not use the digital application form)
Middels onderstaande knop kun je direct solliciteren op deze vacature.Reageer op deze vacature