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  3. PhD-student (ESR4): Stimuli-sensotive particles for TIM-3/Galectin-9 targeting

PhD-student (ESR4): Stimuli-sensotive particles for TIM-3/Galectin-9 targeting

Development of stimuli-sensotive particles for tumour-selective targeting of TIM-3/Galectin-9 This PhD student position offers an exciting and innovative …

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Arbeidsvoorwaarden

Standplaats:
Hanzeplein, Groningen, Groningen
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Opleidingsniveau:
WO

Functieomschrijving

Development of stimuli-sensotive particles for tumour-selective targeting of TIM-3/Galectin-9
This PhD student position offers an exciting and innovative research project that aims to develop targeting of the TIM-3/Galectin-9 immune checkpoint for cancer immunotherapy and will result in a PhD thesis. Research by the UMCG has uncovered immunostimulatory effects of Gal-9 as well as direct anti-tumour cytotoxic activity of Gal-9. However, Gal-9 has pleiotropic functions and its therapeutic activity needs to be restricted to the tumour micro-environment. In this project, the development of tumour-selective nanoparticles with Gal9 and/or bispecific antibodies is pursued for cancer immunotherapy. This research project will end with a PhD thesis defense at the University of Groningen.


Keywords: Drug-delivery, Galectin-9, surface modification nanoparticles, microparticles, bioanalysis

Key Responsibilities:
- Development and characterization of tumor-selective nanoparticles by means of immobilizing antibodies on the particle surface or within porous particles
- Further optimization of the particle properties for long-term drug release and specific targeting of Galectin-9
- Development and optimization of polymeric scaffolds for realistic cell growth conditions
- Immobilization of selected proteins and antibodies on or within particles using layer-by-layer deposited polymer networks / hollow capsules
- Ensuring controlled delivery of particles to targets and a controlled release of immobilized active material on-target via suitable triggers (pH, etc.)
- Various encapsulation, release and surface modification activities
- Operation, optimization and further development of a bioanalysis platform that uses functionalized microparticles (model tumor cells) as sensors (Measurement principle: Whispering Gallery Modes)
- Optimization of the in vitro test conditions for a realistic simulation of the in vivo conditions
- Management, presentation and publication of research data

Functie-eisen

- You are in the first four years of your research career and not have a doctoral degree
- Residence duration in Germany does not exceed 12 months in total within the last 3 years
- MSc in chemistry, biochemistry,biotechnology
- Proven track record in one or more of the following fields:
Drug-delivery systems
Encapsulation and release of biomolecules
Surface modification and functionalization, nanoscale coatings, polymer systems
Nanoparticle / microparticle synthesis
Analysis of biomolecular interactions e.g. protein-protein, antibody-antigen
Biosensors and bioanalysis
- Collaboration skills, demonstrating agility and initiative. Ability to communicate fluently and effectively in English
- German language or the willingness to learn German is advantageous

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

Conditions

A PhD student position for 3 years as part of a Marie Curie Actions Innovative Industrial Doctorate training network. 1st Hosting institution: Location: Surflay, Berlin, Germany, duration: 18 months. 2nd Hosting institution: Location: UMCG, Groningen, Netherlands, duration: 18 months. Intended start date: June 2019. Benefits according to EU MCA regulations.

Applying for a job
Please send your application to recruitment@surflay.com as job application ESR4 Stimuli-sensotive particles for TIM-3/Galectin-9 targeting. The application deadline is 30 April 2019.;
(please do not use the digital application form)

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