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  3. PhD Student: Guardians of intrinsically disordered proteins

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PhD Student: Guardians of intrinsically disordered proteins

While control of disorder of proteins plays a crucial role in the physiology of cells, we do not understand how cells guard the transitions between different …

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Hanzeplein, Groningen, Groningen
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 2495 - € 2495 per maand
Opleidingsniveau:
WO

Functieomschrijving

While control of disorder of proteins plays a crucial role in the physiology of cells, we do not understand how cells guard the transitions between different phases of intrinsically disordered proteins (IDPs), liquid, gel or amyloid. A striking finding in recent years is that nuclear transport factors can protect against toxicity from disease-related IDPs. Vice versa, chaperones have been found to act on nuclear transport. With a consortium of experts on the nuclear pore complex, chaperones and aggregation pathology, we aim to elucidate how nuclear transport receptors and chaperones act as guardians of IDPs to ensure proper nuclear pore complex function and to protect against pathological aggregation. With this consortium, we are in a unique position to make a crucial step forward as we can address the problem through a complementary set of in silico, in vitro, and in vivo approaches. The knowledge obtained is expected to be vital to the understanding of neurodegenerative diseases caused by IDPs.

Functie-eisen

MSc in bio-molecular sciences, and expertise in the areas of molecular biology and biochemistry.
You are a team player, highly motivated, self-driven, and have a high level of written and spoken English.

You are expected to independently conduct a research project embedded in the Cellular Biochemistry group of Prof. Liesbeth Veenhoff at ERIBA in Groningen, and to collaborate with other scientists in the consortium (the Molecular Cell Biology groups of Prof. Harm Kampinga and Dr. Steven Bergink at BSCS-UMCG, Computational Biophysics group of Prof. Patrick Onck at ZIAM and the Biophysics group of Prof. Cees Dekker at the Kavli Institute.

Eligibility criteria
- The applicants can be of any nationality.
- The candidate should have the required qualifications and experience for the position.
- Applicants should be proficient in written and spoken English.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

Conditions

- A research project aimed at impact at the highest international level.
- Mentoring, supervision and training.
- Access to state-of-the art infrastructure.
- A stimulating international research environment.

The UMCG offers a salary of € 2.495 gross per month in the first year up to a maximum of € 3.196 gross per month in the last year. In addition, the UMCG will offer you 8% holiday pay and 8.3% end-of-year bonus.
It concerns a full time appointment (36 h/week) for a period of four years to be concluded with a PhD examination. After one year, the performance of the candidate will be evaluated to decide whether there is sufficient progress to expect a successful completion of the PhD thesis within the coming three years.
Duration of the contract: One year with possibility for extension (funding available for four years)

More information
For more information about this vacancy you may contact:
Prof. Liesbeth Veenhoff, Team leader, ERIBA; email l.m.veenhoff@rug.nl (please do not use email address for applications)

Information about the host lab: http://eriba.umcg.nl/groups/cellular-biochemistry/
Information about ERIBA: http://eriba.umcg.nl/
Information about Groningen: http://portal.groningen.nl/en

How to apply
Full applications including a resume and a motivation letter will receive consideration if received before September 15th 2020, interviews are between the 22th and 30th of September. You can only apply using the digital application form at the UMCG website and upload the relevant documents. Applications using the indicated email address will not be processed. Following your application you will receive an email confirmation.