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PhD students: Unraveling the mechanisms that control plasma lipid levels

In one project the PhD student will make use of CRISPR/Cas9 technology to inactivate several components of the endosomal sorting machinery to unravel the …

6 maanden geleden


Hanzeplein, Groningen, Groningen
Tijdelijk contract / Tijdelijke opdracht


In one project the PhD student will make use of CRISPR/Cas9 technology to inactivate several components of the endosomal sorting machinery to unravel the molecular organization of the endosomal sorting machinery in controlling plasma lipid levels. In the second project, the student will translate genetic information from humans to dedicated mouse models and cell systems and vice versa. Both projects will include experiments with cellular (e.g. primary mouse hepatocytes, fibroblasts) and mouse models to investigate the role of the candidate genes in cholesterol uptake, synthesis and secretion. Cells and tissues samples will be analyzed at the cell biological (immunofluorescence), transcriptional, and biochemical (proteomics) level. Under dedicated supervision, you will be responsible to successfully complete your PhD training program, present at national/international scientific conferences, and report in scientific renowned journals.


You have a MSc degree in molecular cell biology, biochemistry, genetics or medical biology, with a strong affinity to molecular biology and genetics. The candidate should be able to work in a team of fellow PhD students and technicians. We are specifically looking for PhD students with strong problem-solving capacities, creative thinking and with experience in molecular and cell biology techniques. Students with 1) working experience with mouse models, 2) certificate for Course on Laboratory Animal Science (Art. 9), 3) certificate for Course in radiation protection (5A or 5B certificate); 4) international research experience; 5) experience in metabolism, in particular lipid metabolism; 6) affinity with bioinformatics or genetic datasets; 7) strong English speaking, and writing skills will be selected with priority. However, enthusiastic talented students without these skills should not be scared off!

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.


A fixed position of four years, 36.0 hours per week.
Your salary is € 2.279,- gross per month in the first year up to a maximum of € 2.919,- gross per month in the last year (scale PhD). In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus and a development budget. The terms of employment comply with the Collective Labour Agreement for Medical Centers (CAO-UMC).

Additional information
Link: www.labpediatricsrug.nl
For more information about this vacancy you may contact:
- Prof. B. van de Sluis – a.j.a.van.de.sluis@umcg.nl
- Prof. J.A. Kuivenhoven – j.a.kuivenhoven@umcg.nl
(please do not use e-mail adresses for applications)

Please submit your application including a letter of intent, detailed curriculum vitae, copies of your certificates, and a list of references.

Additional information

Lab Pediatrics

UMCG Corporate information/research

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