Postdoc position Department of Genetics

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Multiple sclerosis (MS) is a complex autoimmune disease that is caused, in part, by the genetic background of patients. Approximately 200 genetic loci have been linked to MS. In each of these loci, dozens to hundreds of SNPs can be potentially causative for the disease. Moreover, the SNPs located in these genetic loci are predominantly found in the non-coding genome, potentially affecting gene expression in disease-specific cell types. The goal of the project is to identify which MS-associated SNPs are able to change gene expression in a cell-type-specific manner using state-of-the-art NGS methods. Using these prioritized SNPs, you will fine-tune expression Quantitative Trait Locus (eQTL) analysis of our large in-house eQTL databases to identify genes and networks affected by SNPs in a cell-type-specific manner. Finally, in collaboration with neurobiology groups within the UMCG, you will validate candidate SNPs and genes in the appropriate cell models. Ultimately, your work will elucidate the genetic underpinnings of MS, paving the way towards better, genetics-based treatments of this devastating disease.

This project is a three-year project supported by a grant from the MS research foundation. You will carry out the project by performing experiments in the lab and analyzing the NGS data generated in collaboration with bioinformaticians within the department. Due to the collaborative and multi-disciplinary nature of the project, strong communication and interaction skills are a must.

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