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  3. Assistant Professor Cellular signalling in drug efficacy and safety

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Assistant Professor Cellular signalling in drug efficacy and safety

Leiden University, the Faculty of Science and the Division Drug Discovery and Safety of LACDR is looking for an Assistant Professor Cellular signalling in drug efficacy and safety

8 maanden geleden


Einsteinweg, Leiden, Zuid-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 38 uur


The division of Drug Discovery and Safety aims to uncover the molecular mechanisms of cellular signalling that defines the efficacy of anticancer drugs as well as the unanticipated adverse responses on critical normal target tissues. A focus is on the identification of novel drug targets that are involved in cancer dissemination and anticancer drug resistance. Mechanistic understanding of adverse drug reactions is focused on liver and kidney injury, the major organs for toxicity. The approaches involve high throughput functional genomics screening in combination with phenotypic and signalling pathway reporter live single cell imaging. Genetic engineering is applied to establish fluorescent reporter cancer cell lines and human induced-pluripotent stem cell (hiPSC) models and human relevant mutations and knock outs. Omics technologies are applied to identify candidate signalling components and pathways for further investigation. Relevant advanced 3D human organoid model systems are integrated in the research and translation to clinical settings is established. The investigations are part of (inter)national research programs.

  • The assistant professor will scientifically contribute to the above research in the division and actively contribute to the scientific excellence and publication strategies;
  • The candidate will support and guide both undergraduate and graduate students with their mechanism-based investigations;
  • He/she should contribute to the acquisition of research grants and scientific writing;
  • The candidate will also actively contribute to the BSc and MSc program of Bio-Pharmaceutical Sciences, involving the coordination of teaching modules and supervision of internship research.


  • A PhD in a relevant bio-medical sciences discipline or related field;
  • Preferred background in high content screening and/or omics technologies;
  • Several years post-doc experience;
  • Enthousiastic and ambitious;
  • Independent thinker;
  • Expertise in advanced molecular biology techniques and cell signalling;
  • Excellence in teaching and experience in course development;
  • Excellent scientific writing skills;
  • Ideal soft skills to supervise undergraduate and graduate students;
  • Strong team player.


We offer a full-time, (max) 4 year term position. Salary range from €3,637.- to €4,978.- gross per month (pay scale 11 in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses(8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

Leiden University requires teaching staff to obtain the University Teaching Qualification (UTQ). If the successful applicant does not already possess this qualification or its equivalent, he/ she must be willing to obtain this Qualification within two years., There’s a language proficiency of minimum level Cl required for staff who will teach in English.

Additional information

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Enquiries can be made to Bob van de Water, email b.water@lacdr.leidenuniv.nl, telephone +31 715276223. If you have any questions about the procedure, please contact the secretariat of the Division of Toxicology, Anneke Poels, email secretariaattox@lacdr.leidenuniv.nl, telephone +31 715276270.