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Bioinformatician – single cell transcriptomics

The Faculty of Science and Leiden Academic Centre for Drug Research (LACDR) are looking for a Bioinformatician – single cell transcriptomics

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Einsteinweg, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Opleidingsniveau:
WO

Functieomschrijving

The stem cell and regeneration lab at the LACDR led by Prof. M. Drukker is seeking a resident bioinformatician that will work closely with a team of biologists to discover mechanisms of cellular differentiation and drug response. Single cell RNA sequencing pipeline in the lab is producing raw data, that the bioinformatician will analyze in diverse projects related to the differentiation of human induced pluripotent stem cells into peripheral nerves (motor and sensory), muscles, blood and lung progenitors. The context will be normal differentiation and modeling of the effects of mutations associated with human disease (disease modeling), and effects of drugs on single cell transcriptomics. The bioinformatician will be embedded in the research group and will be able to conduct independent projects. Methods of transcriptomics such as 10x, and BART-Seq will focus on characterizing coding and non-coding genes and targeted sequencing of sonRNAs, tRNAs, lncRNAs and more.

Functie-eisen

  • A degree in bioinformatics, biostatistics or a related field;
  • Highly competent in mapping sequencing reads, use of single cell transcriptomics algorithms, e.g. t-SNE, RNA velocity;
  • Application of R, Phyton, MatLab for data analysis and presentation;
  • Preferred: advanced machine learning and biostatistics capabilities;
  • Strong communication skills in the group and collaborators;
  • Preferred: imaging and flow cytometry analysis capabilities;
  • Preferred: training and experience in molecular biology biomedical research.

Conditions

He or she will initially be appointed for one year with the possibility of renewal and the intention to turn the position into a permanent one, based on performance. Salary range from € 2,790.to € 5,127.-gross per month (fulltime, pay scale 10 or 11, depending on experience, in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break. For more information, see the website.

Diversity and work-life balance
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups. LACDR is a highly diverse institute, in culture, background, and gender. We stand for excellence in a caring Institute. We wish to reflect society in all aspects, as we believe that this improves the dynamics in our organization. Therefore, we support and understand the need for a work/life/family balance and consequent varying working hours and places. We believe that doing good science is fun, and goes hand in hand with a friendly culture. In the Netherlands, a maternity allowance is standard for 16 weeks. Child care is available at and near the Bio Science Park.

Additional information

For any questions, you are welcome to contact Micha Drukker, m.drukker@lacdr.leidenuniv.nl.
If you have any questions about the procedure, please contact Marjolijn Lugthart, email m.j.l.lugthart@lacdr.leidenuniv.nl.