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  3. PhD Candidate, Chromatin-inspired supramolecular materials for biomedical application

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PhD Candidate, Chromatin-inspired supramolecular materials for biomedical application

Nucleic acids are well-defined nanoscale building blocks that are programmable, responsive and addressable. Their application in the supramolecular polymer …

5 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Einsteinweg, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
Salarisindicatie:
€ 2222 - € 2840 per maand
Opleidingsniveau:
WO

Functieomschrijving

Nucleic acids are well-defined nanoscale building blocks that are programmable, responsive and addressable. Their application in the supramolecular polymer field is understudied despite the potential to endow these materials with orthogonally responsive character, which is highly desired for numerous applications in the biomedical area. In this project we will use DNA and chromatin proteins to generate supramolecular polymer networks that form hydrogels for applications in drug delivery. Specifically, we will employ protein-based DNA-DNA cross-linkers to fine-tune the properties of the hybrid DNA-based networks by modulating the density and strength of DNA-DNA cross-links.

Functie-eisen

  • Master’s degree in (Bio)Chemistry, Biophysics or equivalent;
  • Good to excellent command of English;
  • Ability to work independently in a multidisciplinary environment;
  • Required experience: Protein expression and purification, organic synthesis of small molecules and their characterization;
  • Experience with the characterization of soft materials is a plus;
  • The PhD research needs to start before December 2018.

Conditions

We offer a position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from €2,222 to €2,840 gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career programme. Candidates from outside the Netherlands may be eligible for a substantial tax break. More at https://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditions.

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Diversity
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Additional information

Enquiries can be made to Dr. Remus Dame, email rtdame@chem.leidenuniv.nl or Dr. Roxanne Kieltyka, email r.e.kieltyka@chem.leidenuniv.nl.
If you have any questions about the procedure, please contact secretary Mrs. Ingrid Bekooy, email bekooy_i@lic.leidenuniv.nl, telephone +31 71 527 4434.

Applications
To apply for this vacancy, please send no later than 30 June 2018 an email to the secretary of the Macromolecular Biochemistry group Mrs. Ingrid Bekooy at bekooy_i@lic.leidenuniv.nl. Please ensure that you join to your application the vacancy number and the following additional documents:

  • A cover letter explaining why you are interested in the position/research topic;
  • An updated CV;
  • The letters of recommendation by 1 or 2 former supervisors;
  • The transcripts of your MSc studies.