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  3. PhD candidate in Biochemistry: Structure of Bacterial Chromatin

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PhD candidate in Biochemistry: Structure of Bacterial Chromatin

The Faculty of Science, Leiden Institute of Chemistry is looking for a PhD candidate in Biochemistry: Structure of Bacterial Chromatin (1.0 FTE).

9 maanden geleden


J.H. Oortweg, Leiden, Zuid-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
€ 2222 - € 2840 per maand


The chromosomes of bacteria and archaea are organized and compacted into a nucleoid. This is achieved by the action of nucleoid-associated proteins that fold the genome by bending, wrapping or bridging it. In our group we investigate using a quantitative approach the mechanisms employed by the various proteins that are involved in DNA organization and compaction both from a molecular and a cellular perspective (Peeters et al., Nature Rev Microbiol, 2015; Dame & Tark-Dame, Curr Opin Cell Biol, 2016; van der Valk et al., eLife, 2017).

The proposed project is part of a recently funded multidisciplinary research programme. The goal of this sub-project is to define by using biochemical and biophysical techniques how DNA binding proteins involved in bacterial and archaeal chromatin organization act to differentially regulate genes in response to interaction with partner proteins and physico-chemical signals.


  • Highly motivated and independent researcher;
  • MSc degree in biochemistry, biophysics or equivalent;
  • Strong affinity with techniques to investigate protein-DNA interactions;
  • Experience with single-molecule techniques is an advantage;
  • Experience with recombinant protein production and purification is an advantage;
  • Able to work and communicate effectively in a multidisciplinary team.


We offer a position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary ranges from €2,222 to €2,840 gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

All our PhD students are embedded in the Leiden University Graduate School of Science www.graduateschools.leidenuniv.nl. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Additional information

Enquiries can be made to Dr. Remus Dame, email rtdame@chem.leidenuniv.nl. Information on the research group can be found at: www.bacterialchromatin.nl. If you have any questions about the procedure, please contact secretary Mrs. Ingrid Bekooy, email i.bekooy@chem.leidenuniv.nl, telephone +31 71 527 4434.

To apply for this vacancy, send no later than 31 May 2018 an email to Mrs. Ingrid Bekooy at i.bekooy@chem.leidenuniv.nl. Please ensure that you enclose the following additional documents quoting the vacancy number in the subject of your email:

  • A letter with your motivation for this position;
  • A CV;
  • Transcripts of courses and grades of BSc and Msc education;
  • Name and contact information of 2-3 references.