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PhD student

The Faculty of Science id looking for a PhD student

Assistant, associate or full professor
scientist within the broad field of animal biology

ongeveer een maand geleden

Arbeidsvoorwaarden

Standplaats:
Einsteinweg, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Opleidingsniveau:
WO

Functieomschrijving

Human cells are coated with a dense array of carbohydrates attached to proteins and lipids termed the glycocalyx. The glycocalyx mediates cell to cell adhesion, signaling, immune cell maturation and pathogen invasion (Figure 1A).  Modification of the glycocalyx sugars can have profound roles in cell-to-cell signaling and pathogen invasion. This PhD project will focus on the design and synthesis of mechanism-based inhibitors for both human and viral enzymes that de-acetylate glycocalyx sugars. This PhD student will then evaluate these molecules as inhibitors for both human and viral esterases using detailed biochemical techniques. Successful inhibitors will then be coupled to fluorophores and affinity groups to produce chemical tools for the detection of carbohydrate esterases in complex mixtures. The PhD student must be flexible and communicative and able to work in both organic and biochemistry labs and learn protein production methods and enzymology techniques.

Functie-eisen

  • Master’s degree in organic chemistry, or equivalent;
  • Proven interest in protein biochemistry;
  • Proficient in English;
  • Excellent communication skills.

Conditions

We offer a full-time 1 year term position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from € 2.395,-  to € 3.061,- gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses(8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness.

Diversity
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Additional information

Enquiries can be made to Dr. Zach Armstrong, email z.w.b.armstrong@lic.leidenuniv.nl.