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PostDoc: Balanced Lethal System Genomics

The Institute for Biology Leiden at Leiden University and Naturalis Biodiversity Center are looking for a PostDoc: Balanced Lethal System Genomics

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Einsteinweg, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

The Institute of Biology Leiden at Leiden University and Naturalis Biodiversity Center are looking for a postdoctoral researcher – in the European Research Council-funded project BALANCED LETHALS – to determine the genomic architecture at the basis of an evolutionary enigma: the balanced lethal system in the salamander genus Triturus (the crested and marbled newts).

Balanced lethal systems represent an evolutionary enigma because they are incredibly maladaptive. Two distinct forms of a chromosome are required for survival, meaning that only heterozygotes are viable, while homozygotes – half of the total reproductive output – perish. Triturus newts are the most illustrious example. Two non-recombining forms of chromosome 1, 1A and 1B, are involved. The unfortunate homozygous offspring that possess either chromosome 1A or 1B twice experience developmental arrest and die halfway through normal embryogenesis. Half of the eggs a female Triturus newt lays never hatch!

The candidate will combine data obtained with Oxford nanopore sequencing, Hi-C chromosome conformation capture and high-resolution linkage mapping to assemble the ~32Gb Triturus genome into chromosomes and determine the genomic architecture underlying the balanced lethal system. All required samples are available and lab work is outsourced.

Functie-eisen

  • PhD degree in biology with proven experience in bioinformatics and whole genome assembly and annotation;
  • A good command of the English language and proven writing abilities;
  • Highly motivated and capable of working both independently and as part of a team.

Conditions

We offer a full-time, fixed-term post from November 1st, 2021 until October 31st, 2023. Salary range from € 2.790,- to € 4.402,- gross per month (pay scale 10 in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses(8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

Diversity
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Additional information

Enquiries can be made to Ben Wielstra, email b.m.wielstra@biology.leidenuniv.nl. If you have any questions about the procedure, please contact Sylvia Maas, email jobs@biology.leidenuniv.nl .