Ongeveer 16 uur geleden - Universiteit Leiden (LEI) - Leiden
The candidate will perform research, and contribute to the teaching tasks of the Mathematical Institute. The candidate may also share into other …
You will investigate the relationship between energy balance, somatic mutations and metabolic subtypes of colorectal cancer, within the framework of a large prospective cohort study. The project is financially supported by the Dutch Cancer Society ...
You will investigate the relationship between energy balance, somatic mutations and metabolic subtypes of colorectal cancer, within the framework of a large prospective cohort study. The project is financially supported by the Dutch Cancer Society (KWF).
The project is part of the Netherlands Cohort Study (NLCS) that is being conducted at Maastricht University, Department of Epidemiology. At baseline of the study in 1986, more than 120,000 men and women aged 55-69 years completed an extensive questionnaire on diet, lifestyle and other risk factors for cancer. Incident cases of cancer in the cohort are identified by annual computerised record linkage with cancer registries and the Dutch pathology registry. In close collaboration with the Dept of Pathology, a large number of tumor tissue samples has been collected for over 3000 incident colorectal cancer cases from the NLCS. Using this material, tissue microarrays (TMA) have been made, and material is available for DNA-extraction. The TMAs and DNA will be used for molecular subtyping of the colorectal cancer cases, with special attention for metabolic subtypes. Altered cellular energy metabolism has been identified as an important feature in cancer etiology and prognosis.
With you, our team will extract DNA and screen tumor DNA for somatic mutations.The metabolic subtyping of tumors will be done by immunohistochemistry on TMA sections for key proteins involved in metabolic pathways. You will participate in these laboratory analyses and subsequently conduct the epidemiological data-analyses on the relationship between various aspects of energy balance, somatic mutations and metabolic subtypes of colorectal cancer. You will interpret these data and describe the results in scientific articles and a PhD thesis.
In order to qualify for a PhD position the candidate must have successfully completed a Master degree in epidemiology, health sciences, human nutrition, molecular life sciences, medical biology or medicine. The candidate must have affinity with molecular (patho)biology and epidemiological research (e.g. registered as epidemiologist A), and interest in nutrition. Candidates must have a very good competence in written and spoken English.
Temporary employment for 4 years.
Your salary would be € 2.222,- gross per month in the first year up to € 2.840,- gross per month in the fourth year according to the PhD-student salary scale.
Each year an evaluation will take place.
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply.
For more information look at the website www.maastrichtuniversity.nl , Support/UM employees/Employment conditions.
For more information: Prof.dr. P.A. van den Brandt, tel. +31(0)43 3882361 or +31(0)43 3882374
Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 16,500 students and 4,000 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.
GROW - School for Oncology and Developmental Biology
GROW focuses on research and teaching of (epi)genetic, cellular and (micro)environmental factors and mechanisms underlying normal (embryonic and fetal) and abnormal (cancer) development, with emphasis on translational research aiming at innovative approaches for individualizing prevention, patient diagnostics and treatment.