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  3. PhD student Molecular metabolic differences at the basis of gender-specific cardiac pressure overload disorders

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PhD student Molecular metabolic differences at the basis of gender-specific cardiac pressure overload disorders

PhD student Molecular metabolic differences at the basis of gender-specific cardiac pressure overload disorders

20 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Robert Schumandomein, Maastricht, Limburg
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 40 uur
Salarisindicatie:
€ 2325 - € 2972 per maand
Opleidingsniveau:
WO

Functieomschrijving

There exists no cure for pressure overload-induced heart failure (PO-HF), a life-threatening

condition affecting millions worldwide. Hypertension and aortic stenosis are leading risk factors of PO-HF. Interestingly, premenopausal women are at lower risk of developing PO-HF. Our current molecular understanding of what triggers heart failure and determines its progression in both genders remains incomplete. Our team recently showed that changes in cardiac energy substrate uptake and cardiac mass precede the drop in energy status and cardiac dysfunction. In collaboration with the academic hospital (cardiology), the current translational project will investigate PO-HF development in a gender dependent manner and explore the potential of a chosen therapeutic target. Hereto, you will 1) study the (patho)physiological role of this target in substrate uptake and protein synthesis in ex vivo rat and in vitro human cardiomyocytes as well as human cardiac biopsies, 2) set-up an in vivo myocardial imaging toolbox, and 3) test the effectiveness of an existing drug in restoring cardiac function in PO-HF.

Functie-eisen

This PhD Studentship for a 1.0 f.t.e. position for 4 years is funded by the Dutch Heart Foundation (Nederlandse Hartstichting). Eligible are enthusiastic candidates with a finished Master’s degree in Molecular Life Sciences, Health Sciences, Biology, or Medicine. Experience with cell culturing (including human stem cells), rodent handling, Western blotting, standard biochemical techniques, radioisotope labeling, Langendorff perfusion, microscopic staining, in vivo PET scanning is appreciated. We welcome good team collaboration and communication skills, as well as willingness to participate in international collaborations.

Conditions

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website http://www.maastrichtuniversity.nl > Support > UM employees.

Additional information

For questions about the vacancy you can contact:

Dr. Miranda Nabben, m.nabben@maastrichtuniversity.nl or to

Prof. Jan F.C. Glatz, glatz@maastrichtuniversity.nl

Proven interest/performance in the field is preferred. 

• A detailed CV, including your nationality, country of birth and education;

• Names and addresses of two referees;

• A covering letter highlighting your research experience/capabilities;

• Copies of your bachelor and master degree transcripts;

• Evidence of your proficiency in the English language, if applicable