Ongeveer 20 uur geleden - Academisch Medisch Centrum (AMC) - Amsterdam
Voor wat betreft de patiëntenzorg zal de kandidaat ontwikkelingsonderzoeken verrichten conform landelijk protocol en de resultaten daarvan rapporteren aan oude…
The number of people with type 2 diabetes (T2D) is dramatically increasing worldwide. The most potent strategies to combat T2D are increasing physical activity and restricting food intake. Cold exposure has recently received much interest ...
The number of people with type 2 diabetes is dramatically increasing worldwide. The most potent strategies to combat type 2 diabetes mellitus are increasing physical activity and restricting food intake. However, these are not easily achieved and additional strategies are needed. Cold exposure has recently received much interest as a potential therapy for obesity and diabetes, as it can increase energy metabolism and brown adipose tissue.
We recently showed that in patients with diabetes, cold acclimation not only increases energy expenditure, but also insulin sensitivity by more than 40%. We have strong indications that skeletal muscle is also responsible for this improvement. These promising findings provide opportunities for novel treatment strategies for type 2 diabetes.
Therefore this project will focus on testing the effect of different temperature interventions for the treatment of type 2 diabetes. The goal will be the development of a cooling acclimation therapy aimed at increasing long-term insulin sensitivity.
We are looking for a highly motivated candidate with a recent master degree Biomedical Sciences, Health Sciences, Biology, Medicine or similar (life science) education.
The PhD candidate should have interest in performing small-scaled human intervention studies with detailed phenotyping. The experiments will require skillful and frequent contact with the volunteer patients. The techniques that will be used will encompass insulin clamp techniques and indirect calorimetry.
Your salary would be € 2.222,- gross per month in the first year up to € 2.840,- gross per month in the fourth year according to the PhD-student salary scale.
Each year an evaluation will take place.
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply.
For more information look at the website www.maastrichtuniversity.nl , Support/UM employees/Employment conditions.
The department of Human Biology and Movement Sciences is set within the NUTRIM research school of the Faculty of Health, Medicine and Life Sciences at Maastricht University.
A large part of the research performed at the department of Human Biology and Movement Sciences, Maastricht University, is devoted to the (dys)regulation of human energy- and substrate metabolism, primarily in relation to obesity and related metabolic disorders such as type 2 diabetes mellitus.
Within our thermophysiology research group, we have special interest in human whole body physiology, and in brown adipose tissue and skeletal muscle. To this end, Maastricht University has unique facilities to perform human translational studies, and a new Metabolic Research Unit has recently been opened, including clamp facilities, imaging technology and whole body respiration chambers.
For more detailed information about this vacancy, please contact:
Prof. Dr. Wouter van Marken Lichtenbelt, Department of Human Biology/Movement Sciences, Maastricht University, Phone: +31 43 3881629.
Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 16,500 students and 4,000 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.NUTRIM School of Nutrition and Translational Research in Metabolism
NUTRIM School of Nutrition and Translational Research in Metabolism initiates and catalyzes translational research into nutritional health benefits and risks focusing on metabolic and chronic inflammatory diseases. Through its research master and PhD programme NUTRIM aims to educate scientists of high academic excellence and ambassadors to support and develop the filed of nutrition, metabolism and toxicology within and outside the Netherlands. 16 Biomedical, clinical, and behavioural-science departments are incorporated within NUTRIM. The school is a partner in the national Top Institutes TI Food&Nutrition, TI-Pharma and the Centre for Translational Molecular Medicine (CTMM). These unique consortia of government, industry and research aim to stimulate the transfer of knowledge generated in fundamental research to Dutch industry and thus to strengthen its innovative power and competitive strength.
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