1 dag geleden - Universiteit Utrecht (UU) - Utrecht
Utrecht University's Faculty of Humanities is looking for a Postdoc position in the Horizon2020 project “Integrity” (0.8 FTE). Are you interested? Then please …
The division of Cell Biology of the Biology Department of Utrecht University is looking for a 1-year postdoc position Synaptic physiology. Are you interested? Then please read the full profile and apply.
This project is part of a grant from Alzheimer Nederland 'Amyloid β-induced pathology of inhibitory synapses'. One of earliest events in Alzheimer’s disease (AD), before clinical symptoms occur, is extensive synaptic loss and dysfunction within brain networks. While previous studies have focused on Aβ-induced changes in glutamatergic and cholinergic synapses, in this project we will study how Aβ oligomers affect synaptic transmission at inhibitory synapses. We will characterize Aβ-induced pathology of inhibitory synapses using a combination of electrophysiology and two-photon microscopy and compare our findings with inhibitory synaptic changes that occur in a mouse model for amyloidosis at the early stage of the disease.
You are a motivated postdoctoral fellow with strong analytical skills and a broad interest in neuroscience. You should be an experienced electrophysiologist (patch clamp technique) with a solid background in synaptic physiology. Ideally, you would also have experience in imaging, but this is not required.
Utrecht University has great ambitions for its teaching quality and study success rates. This also applies to its clear research profiles which are centred around four themes: Sustainability, Life Sciences, Youth & Identity, and Institutions. Utrecht University plays a prominent role in our society and contributes to finding the answers to topical and future societal issues.
The Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty's academic programmes reflect developments in today's society.
The Synaptic Physiology lab, led by Dr Corette Wierenga, is embedded within the division of Cell Biology of the Biology Department of Utrecht University, which includes several research groups and is headed by Prof Casper Hoogenraad and Prof Anna Akhmanova. The common goal is to gain insight into basic cellular processes and in this way to provide mechanistic basis for devising therapies for cancer, metabolic and neurological diseases. Research topics within the division include: mechanisms underlying cytoskeletal dynamics, membrane transport and signalling pathways that underlie cell proliferation and differentiation, neuronal development and synaptic plasticity. We investigate cellular processes at a broad range of levels, from single molecules and protein networks to cells, tissues, and whole organisms.