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  3. PhD position Image-guided treatment of brain malignancies with radioactive holmium microspheres (1.0 FTE)

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PhD position Image-guided treatment of brain malignancies with radioactive holmium microspheres (1.0 FTE)

Utrecht University's Faculty of Veterinary Medicine is looking for a PhD candidate. Are you interested? Then please read the full profile and apply.

9 maanden geleden


Domplein, Utrecht, Utrecht
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 40 uur
€ 2222 - € 2840 per maand


An innovative minimally invasive image-guided treatment approach for brain tumors will be developed in a consortium of Veterinary, Medical, and Engineering Sciences. The project is funded by NWO. In this project the effectiveness of radioactive 166-holmium microspheres for image-guided intratumoral treatment will be evaluated by studying the intratumoral injection approach, clinical safety and efficacy in an experimental tumor model. Furthermore, the clinical efficacy will be investigated in a translational model for human patients: veterinary patients with brain tumors.

The candidate will be positioned at the Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, and will be part of a dynamic, multidisciplinary team. You will be involved in pre-clinical research which includes optimization of a needle injection approach, image-guided dosimetric monitoring of microsphere distribution in tissue and evaluation of feasibility/safety/efficacy in a tumor model (lab animal). You will also participate in the recruitment, clinical staging, treatment, and follow-up of clinical veterinary patients in the setting of the academic veterinary teaching hospital (University Veterinary Medical Center Utrecht). The candidate will be part of the Holmium Translational Research Group, which is coordinated by Dr. Frank Nijsen at the Department of Radiology and Nuclear Medicine of the Radboudumc Nijmegen, where a parallel PhD project focuses on the medical engineering of a dedicated needle-administration device and imaging-based dosimetric monitoring system. It is our goal to translate the outcomes of these research projects into a new treatment option for human patients.


We are looking for a highly motivated candidate with an interest in combining patient-related clinical research with more in-depth pre-clinical feasibility and modelling studies in a laboratory and medical imaging environment. You preferably have an interest in or experience with high-tech medicine, clinical physics, medical imaging techniques (CT, MRI, SPECT) and radioactivity (Radiation protection level 5b, 4b, or 3).

A degree in veterinary medicine and experience with animal experiments (including Laboratory animal course certification (article 9)) would be an advantage.


We offer a fulltime position, initially for a period of three and a half years, with a critical evaluation after one year. The gross salary - depending on previous qualifications and experience - ranges between €2,222 and €2,840 (scale P according to the Collective Labour Agreement Dutch Universities) gross per month for a full-time employment. Salaries are supplemented with a holiday allowance of 8% and a year-end bonus of 8,3%. We offer a pension scheme, (partly paid) parental leave, collective insurance schemes and flexible employment conditions (multiple choice model). More information is available at: working at Utrecht University.

Additionele informatie

For more information, please contact Dr. Sebastiaan (Bas) van Nimwegen, coordinator at Vetenary Medicine, via s.a.vannimwegen@uu.nl or Dr. Frank Nijsen, PI of the project and group leader of the Holmium Translational Research Group, via Frank.Nijsen@radboudumc.nl.