PhD position in protein lipidation (1.0 FTE)
Interested in chemical biology and proteomics techniques to study the role of protein lipidation in neurological disorders? Read more
- Domplein, Utrecht, Utrecht
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 38 - 40 uur
- € 2395 - € 3061 per maand
Signalling events between proteins, as well as protein localization, are highly and specifically regulated by the post-translational modifications (PTMs) that they can transiently harbour. Of these PTMs, phosphorylation, glycosylation and acetylation have been widely studied and characterized. Protein lipidation, the covalent attachment of a lipid group to a protein, is much less studied, but thought to be equally important. In addition to its well-established important role in fundamental biology, protein lipidation has been associated with multiple neurological diseases, including Huntington’s disease and Alzheimer’s disease.
In this project, you will work at the interface of chemistry and biology. You will contribute to the development of new chemical biology and proteomics tools to study the regulation of protein lipidation, focusing on S-palmitoylation, aiming to reveal how these modifications affect brain proteins, especially those that are linked to neurological diseases. You ideally have a background in chemical biology, hands-on MS experience is preferred, but not essential at the start.
We are looking for a versatile and driven candidate who has:
- a MSc in Chemical Biology or a related field;
- excellent written and oral proficiency in English;
- the ability and enthusiasm for working both independently and collaboratively in a highly multidisciplinary environment;
- significant knowledge of, and experience with working in a chemical biology lab;
- a team player spirit.
Ideally, you also have:
- experience in proteomics mass-spectrometry;
- good knowledge of organic synthesis;
- excellent writing skills;
- experience in cell culturing techniques.
- a chance to become part of a team of highly skilled Researchers;
- a full-time position for 4 years in an international working environment;
- a full-time gross salary that starts at €2,395 and increases to €3,061 per month in the fourth year (scale P of the Collective Labour Agreement Dutch Universities (cao));
- benefits including 8% holiday bonus and 8.3% end-of-year bonus;
- a pension scheme, partially paid parental leave, and flexible employment conditions based on the Collective Labour Agreement Dutch Universities.
In addition to the employment conditions laid down in the CAO for Dutch Universities, Utrecht University has a number of its own arrangements. For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model. This is how we like to encourage you to continue to grow.
More information about working at the Faculty of Science can be found here.
If you have any questions that you’d like us to answer, please contact Dr. M.P. Baggelaar via email@example.com.
Do you have a question about the application procedure? Please send an email to firstname.lastname@example.org.