PhD/Postdoc position in modeling cellular decision making during multicellular development (1.0 FTE)
Take part in an exciting team effort by world-leading scientists to decipher how individual cells acquire their specialized fate.
- Domplein, Utrecht, Utrecht
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 38 - 40 uur
- € 2325 - € 2972 per maand
The Ten Tusscher lab invites applications for a PhD or postdoctoral research position in Computational Developmental Biology. The focus of the project will be to reveal the regulatory logic of cellular decision making in the context of animal development. Specifically, we seek to better understand how precursor cells commit to a specialized cellular fate, choose between distinct cellular fates, and coordinate fate decisions with a permanent arrest of cell division. To address these questions, we will develop quantitative dynamic models of cell fate decisions. Aim of the project is to reveal the key players, unravel the architecture of the regulatory network they constitute as well as the temporal dynamics this generates to decipher how all of this together shapes cell fate decisions. Developed models will be based on high quality, detailed experimental data obtained through the latest technologies in transcriptome, epigenome, and proteome analysis, and the project will be carried out in close collaboration with specialists in C. elegans development (van den Heuvel lab, UU, Korswagen lab, Hubrecht Institute), single-cell analysis (Korswagen and van Oudenaarden labs, Hubrecht Institute), and proteomics techniques (Vermeulen lab, Radboud University Nijmegen).
The successful candidate will become part of the highly interactive Computational Biology community at Utrecht University. This will include daily interactions with fellow Researchers in the Theoretical Biology and Bioinformatics group, as well as regular meetings with our consortium partners at the Developmental Biology group, Hubrecht Institute and Radboud University. Our PhD research students are associated with the PhD programme “Computational Life Sciences” of the Utrecht University Graduate School of Life Sciences, and will have access to the courses, retreats, and infrastructure of the Graduate School.
We are looking for a curious and ambitious junior scientist who
- holds a Master’s or PhD degree in Computational Biology, Applied Mathematics, Physics, Computer Science, or a related field;
- has a strong interest in developmental biology and gene regulation;
- has previous experience with independent research;
- has experience with data analysis, modeling, numerical mathematics and programming;
- has been trained in scientific writing, communication and presentation in English;
- has the motivation to work in an ambitious, multidisciplinary and international research team.
- a full-time position with an evaluation after one year (PhD candidate: for four years total, Postdoc: three years);
- embedding in a great team of top Computational Biologists and Life Sciences Researchers;
- a full-time gross salary starting for PhD candidates at €2,325 and increasing to €2,972 per month during the appointment (scale P according to the Collective Labour Agreement Dutch Universities (cao)) The salary for Postdocs depends on previous qualifications and experience: the gross salary ranges between €3,255 and €4,978 per month (scale 10/11 of the Collective Labour Agreement of Dutch Universities) for full-time employment;
- the salary is supplemented with a holiday allowance of 8% and an end-of-year bonus of 8.3% per year;
- a pension scheme, partially paid parental leave, and flexible employment conditions (based on the Collective Labour Agreement Dutch Universities).
In addition to the employment conditions laid down in the cao for Dutch Universities, Utrecht University has a number of its own arrangements. For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model. This way we like to encourage you to continue to grow.
More information about working at the Faculty of Science can be found here.
If you have any questions, please contact Prof Kirsten ten Tusscher via K.H.W.J.tenTusscher@uu.nl.
Do you have questions about the application procedure? Please send an email to email@example.com.