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  3. Postdoc position Analysis of the MHC class I ligandome during bacterial infection and contribution of posttranslationally modified peptides to immune defense (1.0 FTE)

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Postdoc position Analysis of the MHC class I ligandome during bacterial infection and contribution of posttranslationally modified peptides to immune defense (1.0 FTE)

The Faculty of Veterinary Medicine at Utrecht University is looking for a Postdoctoral Researcher. Interested? Read more and apply.

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Domplein, Utrecht, Utrecht
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 40 uur
Salarisindicatie:
€ 3123 - € 4138 per maand
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

We are looking for a highly motivated Postdoc to work on a project funded by the Netherlands Organisation for Scientific Research (NWO), to determine to which extent proteasome-mediated post-translational peptide modification plays a shaping the antigenic landscape on cells infected with intracellular pathogens. The post doc will join the group of Alice the Immunology Division of the Faculty of Veterinary Medicine, Utrecht University, The Netherlands. Research by this focuses on the cellular mechanisms underlying immune defense against intracellular pathogens, with the aim to translate obtained knowledge for development of next generation vaccines.


Project description

In how many flavors does the MHC peptidome come? In this project you will combine immunological, biochemical and computational biological, bioinformatics expertise to unravel the representation of a ‘novel’ peptide species, generated proteasome-mediated peptide fusion, (i.e. spliced peptides) within the MHC peptidome on infected cells. You will address mechanisms underlying generation of spliced peptides, and use a preclinical model to examine their immunological relevance.

Your responsibilities will include the design and execution of experiments based on leads from a previous project, communication with international collaborators, data analysis, and manuscript preparation. In addition, you will have opportunity to co-supervise several PhD students. You are expected to develop novel ideas and have the ambition grant applications to support your future career.

Functie-eisen

We seek an experienced and ambitious immunologist/biochemist at the Postdoctoral level with an interest in fundamental research, and the drive to pursue a multi-disciplinary project. Excellent organisational and communicative skills and to work both independently and as part of an (inter)national team are an asset.


Requirements
- PhD in Cell Biology, Biochemistry or Immunology;
- Expertise in molecular biological, biochemical and/or immunological techniques;
- Record of relevant peer-reviewed publications;
- Excellent English oral, written and presentation skills;
- Ability to think critically and creatively.

Arbeidsvoorwaarden

We offer a fulltime position, initially for a period of a year, with the possibility of extention. The gross monthly salary is based on experience and qualifications, and ranges from a minimum of €3,123 to a maximum of €4,138 (i.e. salary scale 10 or 11 according to the Collective Labour Agreement for Dutch Universities) on a fulltime basis. Salaries are supplemented with a holiday allowance of 8% and a year-end bonus of 8,3%. Utrecht University offers excellent secondary benefits including collective insurance schemes, an excellent pension scheme and flexible employment conditions. For more information: Working at Utrecht University.

Additionele informatie

For more information, please contact Alice Sijts (Associate Professor of Immunology), via e.j.a.m.sijts@uu.nl or 00 31 30 253 24 71.