Postdoctoral position Enzymatic Depolymerization and characterization of synthetic Polymers
The Van ‘t Hoff Institute for Molecular Sciences has a postdoctoral position available for 12 months to explore research at the forefront of …
- Science Park, Amsterdam, Noord-Holland
- Vast contract
- Uren per week:
- 38 - 38 uur
- € 2790 - € 4402 per maand
The Van ‘t Hoff Institute for Molecular Sciences has a postdoctoral position available for 12 months to explore research at the forefront of biocatalysis and analytical chemistry in the area of enzymatic depolymerization and analytical characterization of synthetic polymers. The project was funded by Holland Chemistry and is a public-private partnership with companies DSM and Innosyn. The high multidisciplinary and the feasibility of the project will be assured by the close collaboration between the Biocatalysis group (which is part of Synthesis & Catalysis theme) and the Analytical Chemistry group of our institute.
What are you going to do?
You will work on the important problem on the accumulation of plastic materials in the environment and the necessity to: (i) analytically characterize the process of plastic degradation and (ii) to develop efficient depolymerization and recycling strategies. Although academia and industry have invested significant efforts in the development of new plastic materials that are inherently degradable in the environment, the replacement of traditional plastic materials with new generation biodegradable alternatives is not always possible for technical reasons. However, it appears that the degradability of the traditional polymers can also be tuned because it is linked to their particular physicochemical and structural properties. Notably, these polymers’ properties of performance vs. degradability have not been fully elucidated until to date. Therefore, this project aims at: (i) discovering, characterizing and engineering biocatalysts for the selective degradation of synthetic polymeric materials; (ii) developing advanced analytical techniques to elucidate the process of depolymerization and determine the key factors that influence the polymer degradability.
The project has already started, and significant advancements have been achieved. In the area of biocatalysis, depolymerizing enzymes have been identified and new variants have been preliminary obtained by introducing mutations through structural, in silico studies. In the area of analytical chemistry, analytical methods have been developed for the mass characterization of partially digested polymers and oligomers.
The continuation of the research project will be focused on two complementary work-packages:
- development of enzymatic and analytical tools for the characterization of the microstructure of synthetic polymer nanoparticles;
- the engineering of enzymes to enable the chemo selective degradation of polymer nanoparticles to oligomers as well as degradation of selected polymers back to monomers.
What do we require?
A PhD degree in chemistry is required. Due to the high multidisciplinary nature of the project, applicants with a focus and/or previous research experience in the following sub-disciplines will have a clear advantage: knowledge in biocatalysis (including in silico analysis of enzymes’ structures, enzyme engineering) and analytical chemistry (i.e., characterization of (bio)molecules through HPLC chromatography and mass spectrometric approaches).
The ability to collaborate and adapt in an international team is required and candidates must possess good communication skills in oral and written English.
Due to limitations in recruitment budget we will preferably consider candidates that are currently in Europe.
We offer a temporary contract for 38 hours a week, preferably starting on 1 June 2021 for the duration of 12 months.
The salary, depending on relevant experience before the beginning of the employment contract, will be €2,790 to €4,402 (scale 10) gross per month, based on a fulltime contract (38 hours a week). This is exclusive 8% holiday allowance and 8.3% end-of-year bonus. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable.
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