Outstanding postdoc in single-molecule studies of DNA replication

  • WO
  • Tijdelijk
Delft University of Technology (TU Delft)


During our lifetimes, we copy approximately a lightyear’s worth of DNA, and how the different components of the molecular machinery (the replisome) work together to achieve this successfully is an area of highly active research.  Here, you will take on the exciting challenge of understanding the dynamics of DNA replication by reconstituting and studying the activity of eukaryotic replisome at the single-molecule level, on bare DNA and/or chromatin substrates. You will examine replisome composition, replisome motion dynamics, and the interplay between these two quantities; and examine how these change in the context of chromatin or obstacles on the DNA. To do so, you will develop and harness novel biophysical instrumentation (e.g. fluorescence imaging, single-molecule force spectroscopy, or other forms of microscopy) while making effective use of supporting biochemical technologies (protein purification, DNA sequencing). You will analyze the resulting datasets using biophysical modelling, interact with collaborators in molecular biology and biochemistry in the United Kingdom (involving extensive visits), and in doing so, publish high-quality scientific papers to advance this exciting field.


We are looking to hire an outstanding experimentalist for this exciting NWO-funded collaborative project at the interface of biophysics and biochemistry. We have an opening for an outstanding postdoc trained in biophysics who is keen to advance the field of DNA and chromatin replication dynamics from a mechanistic perspective. You will be responsible for proposing, planning, and carrying out biophysical experiments and for analysing data. You will interpret the results of your biophysical experiments on the basis of detailed analysis of the data and in conjunction with biochemical advances in the field. You will both receive state-of-the-art training and, subsequently, provide it to others (e.g. Ph.D. students, new group members). You will provide individual initiative within a context of respectful teamwork. A strong background in biophysics and optics is a necessity. A good command of spoken and written English is a must.


Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context. At TU Delft we embrace diversity and aim to be as inclusive as possible (see our Code of Conduct). Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. Challenge. Change. Impact!


The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

Meer informatie

For more information about these positions, please contact Prof. Nynke Dekker, phone: +31 (0)15-2783219, e-mail: