Leiden

Postdoc Center for Proteomics and Metabolomics

We are looking for a a skilled and highly motivated postdoc for a multidisciplinary research project focusing on the development of novel analytical tools for the spatial (single-cell) glycosylation analysis in tissues of patients suffering from inflammatory bowel disease (IBD). Do you have an analytical mindset, hands-on experience with mass spectrometry imaging, and would you like to develop and apply mass spectrometry in a biomedical setting? Then we would like to meet you!

26.05.2023

Tijdelijk

Leids Universitair Medisch Centrum (LUMC)

Functieomschrijving

As a postdoc you will investigate intestinal glycans in inflammatory diseases by mass spectrometry imaging. In the multidisciplinary GlycanTrigger project, we aim to gain new molecular insights in the transition from healthy to chronic inflammation in patients with IBD. A specific focus lies on the changes in glycosylation of specific cell types involved in this transition. To accurately study the role of protein and lipid glycosylation at the single-cell level, new methods need to be developed that allow spatial and in-depth characterization of glycosylated molecules. You will develop on-tissue mass spectrometry imaging (MSI) methods for in-situ N-, O- and lipid-glycan analysis. The in-situ methods need to be complemented with off-tissue analyses with sufficient analytical sensitivity and depth-of-coverage, e.g. LC-MS-based methods. Ultimately, developed methods will be applied to a well-defined cohort of IBD patients to get insight into the role of glycosylation in IBD. This will be done in collaboration with both local clinicians and international partners from the GlycanTrigger consortium.

Functie-eisen

· You have obtained your PhD in mass spectrometry imaging or analytical glycoscience (or will do so on very short term);

· You have a keen interest in, and ample experience with, mass spectrometry imaging;

· Affinity and experience with computer scripting, and data analysis are a big plus;

· You must be fluent in English, pro-active and performance driven, structured and accurate, and have good communication and writing skills

Bedrijfsomschrijving

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Arbeidsvoorwaarden

You will be employed on the basis of 36 hours per week. Your salary is based on your education and experience and is a maximum of € 5,088 gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).