Postdoctoral fellow in single-molecule biophysics

  • WO
  • Tijdelijk
Delft University of Technology (TU Delft)


Proteins are the workhorses in all living cells and, as such, form the basis of all living systems. In order to fully understand biological processes, it is critical to be able to identify and quantify the proteins in cells at any given time in the cell cycle. This can be done by sequencing since each protein has a unique amino acid sequence. However, practical realisation of protein sequencing remains an enormous challenge. Small sample size, in which the numbers of specific proteins can differ by orders of magnitude, and the necessity to distinguish 20 different amino acids are only a few of the obstacles currently limiting our ability to sequence proteins. Furthermore, proteins cannot be amplified outside the cell, unlike DNA and RNA, which complicates the sequencing task. The plethora of protein modifications and alternative splicing further increases the complexity of the proteome to several million distinct protein molecules in a cell.


We are looking for a highly motivated postdoctoral fellow with significant physics or engineering research experience to develop a novel sequencing technique that probes the protein profile using aptamers with sub-nanometre resolution. This high-resolution method, combined with nanotechnology, will be used for analysing proteoforms, particularly, splicing isoforms and post-translational modifications. We will be able to sequence single proteins and their proteoforms and therefore create the opportunity for single-cell proteomics and screening for on-site medical diagnostics. It will lead to a revolution in biophysics, biotechnology, and healthcare. Do you want to join developoing this ground-breaking technology? Send the application package to Chirlmin Joo. 


The candidate should have a PhD degree in the field of physics or engineering. An application from a candidate who is experienced in biochemistry will be favorably treated, but this is not a requirement. Good communication skills in English are required.


Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context. At TU Delft we embrace diversity and aim to be as inclusive as possible (see our Code of Conduct). Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale.

Challenge. Change. Impact! 


Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. The TU Delft offers a customisable compensation package, a discount on health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged.

For international applicants we offer the Coming to Delft Service and Partner Career Advice to assist you with your relocation. An International Children's Centre offers childcare and there is an international primary school.

Meer informatie

For information about this vacancy, you can contact: Chirlmin Joo, the group leader, email: