PhD candidate Bioanalytical Chemistry
Are you a Chemist or Pharmacist passionate about bioanalytical chemistry and strongly committed to science and research? Would you like to work in a great team on a project involving the development of innovative (enantioselective) analytical techniques, metabolomics, clinical and forensic toxicology, and bioactivity screening? Please apply at VU Amsterdam.
- De Boelelaan, Amsterdam, Noord-Holland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 40 - 40 uur
- € 2395 - € 3061 per maand
New psychoactive substances (NPS) represent a large and diverse range of drugs that have been designed to mimic and replace established illicit drugs. Chemical structures of NPS are constantly changing to avoid banning. Multiple analytical challenges are associated with NPS, such as need for continuous actualization of analytical methods, the lack of reference compounds, the (potential) presence of structural and/or optical isomers, and formation of unknown metabolites. Moreover, knowledge on the pharmacokinetics, toxicokinetics, and pharmacodynamics of NPS is limited, in particular for isomers/enantiomers. However, this information is highly needed from a public health perspective for the worldwide monitoring of high-risk NPS.
This project aims at developing state-of-the-art (enantioselective) analytical strategies for the characterization, identification, and quantitation of structural and optical NPS isomers for subsequent in vitro and in vivo applications. Different mass spectrometry-based analytical approaches will be considered, including liquid chromatography, capillary electrophoresis, supercritical fluid chromatography, and ion mobility spectrometry. With the developed approaches, the PhD candidate will investigate (i) the potential differences in enantioselective in vitro biotransformation of isomers in human liver preparations and cultured human liver cells, and (ii) the differences in pharmacokinetics of NPS isomers and metabolites using in vivo experiments. The toxicity will be assessed using state-of-the-art bioactivity screening assays.
This project will be in close collaboration with groups from the Amsterdam Institute for Molecular and Life Sciences (AIMMS). It will also involve academic and governmental partners such as the University of Amsterdam (UvA), the National Institute for Public Health and the Environment (RIVM), and the Dutch Poisons Information Center (NVIC).
- MSc or equivalent degree in (Analytical) Chemistry, Pharmacy, or (Bio-)Pharmaceutical Sciences
- highly motivated candidate committed to research and showing a strong interest for bioanalysis and clinical and forensic toxicology
- lab experience with analytical techniques such as LC-MS, CE-MS, SFC-MS or ion mobility-MS is a plus
- strong affinity with lab work
- solid oral and written communication skills and comfortable working both independently and in a team
- willing to supervise BSc and MSc student projects.
ConditionsA challenging position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,395 (PhD) per month during the first year and increases to €3,061 (PhD) per month during the fourth year, based on a full-time employment. The job profile: is based on the university job ranking system and is vacant for at least 1 FTE.
The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a duration of 4 years in total.
Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:
- a maximum of 41 days of annual leave based on full-time employment
- 8% holiday allowance and 8.3% end-of-year bonus
- solid pension scheme (ABP)
- contribution to commuting expenses
- a wide range of sports facilities which staff may use at a modest charge
Additional informationAre you interested in this position? Please apply via the application button and upload your curriculum vitae and cover letter until October 29, 2020.
Applications received by e-mail will not be processed.
If you have any questions regarding this vacancy, you may contact:
Name: Dr. Isabelle Kohler
Position: Assistant Professor