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PhD position in bioinformatics and neurochemistry

Are you about to graduate from a MSc degree, do you have an interest in protein structures and good computational skills? Are you interested to figure out which antibodies are good binders for biomarkers in Alzheimer's disease? Please apply to the Vrije Universiteit Amsterdam.

3 maanden geleden


De Boelelaan, Amsterdam, Noord-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
40 - 40 uur
€ 2325 - € 2972 per maand


We seek a new colleague who will work on a collaborative PhD project within the MIRIADE consortium (see below) in the Bioinformatics group at the Vrije Universiteit Amsterdam. The aim is to develop novel approaches in biomarker development for dementias. Crucial is here to develop models to rationalise the prediction how biomarkers, in a specific medium, will be able to bind specific antibodies for detection. Therefore, bioinformatics (especially structural bioinformatics) will play an important role in this research. The specific goal of the PhD project is to develop prediction algorithms for the design of antibody biomarker assays to detect native proteins in CSF and blood. Your main tasks and responsibilities in this project are:

  • Setup a database on successful and failed antibody and immunoassay development
  • Gather initial biomarker assay development data in Madrid (ISCIII).
  • Develop a method to predict the success of antibody binding and immunoassay development.
  • Adapt antibody specificity prediction methods for blood and CSF (ENPICOM).
  • Communicate your work with both biomedical researchers and computer scientists
  • Supervise computer practicals to MSc students (<10% fte)


  • We look for excellent candidates with an M.Sc. degree in Bioinformatics, Chemistry, Biotechnology, Machine Learning or related fields
  • Programming in python
  • Being familiar with structural bioinformatics techniques
  • Being familiar with machine learning methods
To be eligible for this position, the applicant must satisfy the following requirements conform the Marie Curie admission requirements:
  • Must not already hold a PhD;
  • Must be within the first four years (full-time equivalent) of their research career;
  • Must not have resided or carried out their main activity (work, studies, etc.) within the Netherlands for more than 12 months in the three years immediately prior to their recruitment.


A challenging position in a socially involved organisation. The salary will be in accordance with university regulations for academic personnel and amounts €2,325 (PhD) per month during the first year and increases to €2,972 (PhD) per month during the fourth year, based on a full-time employment.

The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a total duration of 4 years.

Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:
  • a maximum of 41 days of annual leave based on full-time employment
  • 8% holiday allowance and 8.3% end-of-year bonus
  • contribution to commuting expenses
  • good paid parental leave scheme
  • child daycare facilities available on campus

Additional information

Are you interested in this position? Please apply via the application button and upload your:
  • curriculum vitae (CV)
    • highlighting research experience
    • including two references we may contact
  • cover letter (CL)
    • including a motivation for this PhD position
    • explaining how you fulfill the requirements for this position
  • BSc and MSc academic transcripts
    • containing all your grades at university level
Are you interested in this position? Please apply via the application button and upload your curriculum vitae and cover letter until 30th of April 2020. The job interviews are planned for mid April, when possible please take them into account when applying for the position. The intended starting date for this position is June 2020.

Applications received by e-mail will not be processed.

Vacancy questions
If you have any questions regarding this vacancy, you may contact:

Name: Caroline Waij
E-mail: informatica.secretariaat.few@vu.nl

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