Ongeveer 24 uur geleden - Universiteit Twente (UT) - Enschede
PhD-student in biomedical sciences or neurosciences
We are looking for a PhD candidate with a MSc in biomedical sciences or neurosciences with a strong background in cell and molecular biology. The candidate should be highly motivated to perform fundamental science applied to a clinical research problem.
- De Boelelaan, Amsterdam, Noord-Holland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 40 - 40 uur
- € 2325 - € 2972 per maand
Approximately one third of the frontotemporal dementia (FTD) cases are characterized by tau inclusions. Despite a causal relation between tau pathology on one hand and neurodegeneration and clinical symptoms on the other, it is unknown how tau pathology causes neuronal dysfunction. Recently, we have developed the first in vitro FTD-tau model that shows a spectrum of tau pathology load and importantly GranuloVacuolar degeneration Bodies (GVBs). Using this model we could demonstrate that GVBs are lysosomal structures that are induced by intracellular tau pathology. We hypothesize that GVBs are induced as a protective lysosomal stress response of the neurons to developing tau pathology that presents a decision point in the pathogenesis. Our in vitro model presents a unique opportunity for further study of the role of GVBs in the transition of FTD-tau pathology to neurodegeneration. This project is aimed to characterize the mechanism of GVB formation and their role in neurodegeneration, ultimately to identify a target in the neurodegenerative pathway that underlies FTD-tau.
- a MSc in biomedical sciences or neurosciences
- Background in cell and molecular biology
- Motivated to perform fundamental science applied to a clinical research problem
ConditionsA challenging position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,325 (PhD) per month during the first year and increases to €2,972 (PhD) per month during the fourth year, based on a full-time employment. The job profile: is based on the university job ranking system and is vacant for at least 1 FTE.
The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a duration of 4 years.
Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:
- 8% holiday allowance and 8.3% end-of-year bonus
Additional informationAre you interested in this position? Please apply via the application button and upload your curriculum vitae and cover letter until 17 october 2019.
Applications received by e-mail will not be processed.
If you have any questions regarding this vacancy, you may contact:
Name: Dr. W. Scheper
Position: supervisor project