Two positions for researcher (PhD Candidate and/or Postdoctoral Researcher) in Biophysics: Imaging of intraflagellar Transport Processes and Chemosensing in living C. elegans

Project description The positions are part of the ERC Advanced Grant awarded to Erwin Peterman How intraflagellar transport shapes the cilium: a single- …

18 dagen geleden


De Boelelaan, Amsterdam, Noord-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
40 uur
€ 2267 - € 4166 per maand


Project description
The positions are part of the ERC Advanced Grant awarded to Erwin Peterman How intraflagellar transport shapes the cilium: a single-molecule systems study (HITSCIL). Subjects of study in this project are the chemosensory cilia of C. elegans, which sense water-soluble molecules in the animal’s environment for chemotaxis. Ciliary development and maintenance depend critically on a specific, microtubule-based intracellular transport mechanism, intraflagellar transport (IFT). Over the past years, the research group has developed a unique set of quantitative, single-molecule fluorescence microscopy tools that allows visualization and quantification of IFT dynamics with unprecedented detail in living animals. The focus now will be on unravelling the connection between ciliary structure, chemosensory function and IFT, from a systems perspective. Four major aims are to: (i) determine how directional changes in IFT are regulated and are affected by external disturbances; (ii) understand the dynamics of the ciliary microtubules and how IFT affects these dynamics and vice versa; (iii) study how sensory ciliary function affects IFT and ciliary structure; (iiii) further develop our (single-molecule) fluorescence microscopy toolbox by improving instrumentation and using better fluorescent probes and sensors.

This multidisciplinary project brings together diverse disciplines like molecular biology, C. elegans genetics, cell biology and neurobiology, quantitative and single-molecule fluorescence microscopy in vivo, image analysis, quantitative data analysis and computer modelling. We are looking for people who are excited to work on an interdisciplinary team, with a strong background in one of the disciplines relevant for the project (biophysics, cell biology, optical microscopy, or related). Candidates are expected to publish their results in international peer-reviewed journals and present their work at (inter)national scientific conferences. A PhD candidate will ultimately produce a dissertation.


Suitable candidates are ambitious and highly motivated to perform research at the highest international level, collaborating in a multidisciplinary environment. Candidates for the PhD position hold an MSc degree in biophysics, physics or cell biology (or similar). Candidates for a position as Postdoctoral researcher have successfully obtained a PhD degree in neurobiology, cell biology, biophysics, advanced optical microscopy or comparable, with demonstrable experience (scientific publications) relevant to the project described above. For both levels, further requirements include:
• affinity with and/or skills in advanced fluorescence microscopy, analyzing images and quantitative data;
• affinity with and/or skills in working with simple model organisms like C. elegans or other living systems;
• excellent communication skills in written and spoken English.


For a PhD candidate, the appointment will be initially for 1 year. After satisfactory evaluation of the initial appointment, it can be extended for a total duration of 4 years. For a Postdoctoral researcher, the appointment will be for a total of 3 years.

You can find information about our excellent fringe benefits of employment at like:
• remuneration of 8,3% end-of-year bonus and 8% holiday allowance
• solid pension scheme (ABP);
• a minimum of 29 holidays in case of full-time employment;
• commuting allowance;
• discounts on collective insurances (healthcare- and car insurance);
• participation in Individual Choices model;
• KinderRijk KDV Boechorststraat provides professional childcare on the VU campus;
• a wide range of sports facilities which staff may use at a modest charge.

The salary will be in accordance with university regulations for academic personnel, for a PhD candidate € 2,267.00 gross per month in the first year up to € 2,897.00 gross per month in the fourth year (salary scale 85) based on a full-time employment.

For a postdoctoral researcher it will range from a minimum € 2,640.00 gross per month in the first year up to a maximum of € 4,166.00 gross per month (salary scale 10), depending on experience, based on a full-time employment.

Additional information

For additional information please contact: Erwin J.G. Peterman.

Applicants are requested to write a letter in which they describe their abilities and motivation for this research project, accompanied by a curriculum vitae, including publication list and two references (names and e-mail addresses).

Please send your application by e-mail before 5 August 2018 to Prof. Dr. Ir. Erwin J.G. Peterman via the application button and mention the vacancy number in the e-mail header.

Any other correspondence in response to this advertisement will not be dealt with.


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