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Zero tolerance: understanding the physiology of the Crabtree-negative yeast Pichia kluyveri through whole-cell modeling

Do you like to carry out fundamental research in an industrially relevant context? Are you interested in biotechnology, microbial cell physiology and would you like to work in a multidisciplinary team of experimentalists, theoreticians and modellers? Please apply at Vrije Universiteit Amsterdam.

ongeveer een maand geleden


De Boelelaan, Amsterdam, Noord-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
32 - 40 uur
€ 2395 - € 3061 per maand


In the life sciences we often make use of model organisms to study their genetics, metabolism or physiology in great detail. However, many biotechnological applications use industrial strains or species that are much more poorly characterized. In this PhD project, we will translate knowledge from the model yeast Saccharomyces cerevisiae to the industrial yeast Pichia kluyveri. We ask why Saccharomyces is Crabtree positive (makes ethanol) and Pichia is not. We do this by combining physiological characterisations with genome-scale metabolic modeling. We will work closely together with an industrial partner.

Your duties

  • perform research and write publications as part of your thesis
  • contribute to the teaching of the group
  • contribute to tasks related to the organisation and well being of the group


  • a Master's degree in biotechnology, biophysics, systems biology or equivalent that that prepared you (to learn) to do both experimental work and computer modeling
  • motivation, curiosity, independence and a drive to make the best out of your PhD
  • good communication skills


A challenging PhD position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,395 (PhD) per month during the first year and increases to €3,061 (PhD) per month during the fourth year, based on a full-time employment. The job profile: is based on the university job ranking system and is vacant for at least 0.8 FTE.

The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a duration of 4 years.
Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:
  • a maximum of 41 days of annual leave based on full-time employment
  • 8% holiday allowance and 8.3% end-of-year bonus
  • contribution to commuting expenses
  • optional model for designing a personalized benefits package
  • discounts on collective insurances (healthcare- and car insurance)

Additional information

Are you interested in this position? Please apply via the application button and upload your curriculum vitae and cover letter until 28 August, 2020.

Applications received by e-mail will not be processed.

Vacancy questions
If you have any questions regarding this vacancy, you may contact:

Name: Prof. dr. Bas Teusink
Position: Project leader
E-mail: b.teusink@vu.nl
Telephone: 020-5989435

No agencies


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