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Phd in Model-based production of tailor made microbial oils

Are you ready for a PhD position in Biotechnology, Bioinformatics, or molecular life sciences? Do you have a strong affinity with both wet lab and …

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Arbeidsvoorwaarden

Standplaats:
Droevendaalsesteeg, Wageningen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
Opleidingsniveau:
WO

Functieomschrijving

Are you ready for a PhD position in Biotechnology, Bioinformatics, or molecular life sciences? Do you have a strong affinity with both wet lab and computational work? We offer you the chance to give your career a boost in Wageningen!

As a PhD candidate, you will combine state-of-the-art molecular tools available at the hosting lab to build strains, fermentation experiments in small scale (1.5L) bio-reactors, computational modelling of metabolism and analysis of omics and bioreactor data sets. Machine learning and data integration techniques will be used to iteratively refine the designs towards an optimal biocatalyst in our project.
The project is about metabolic modelling which provides a solid foundation both for increased understanding of cellular metabolism, and for tailoring of microbial chassis towards innovative biotechnological applications. In this project we will develop a solution to provide a sustainable replacement of palm-oil that will contribute to meeting the growing demand of oils and fatty acids.
We will use the well-known lipid producer yeasts Cutaneotrichosporon curvatus (formerly known as Cryptococcus curvatus) and Yarrowia lipolytica. Through a combination of model driven experimentation followed by experimental characterization we will develop strategies to control not only the amount but also the chain and or saturation level of the produced fatty acids.
In this project our laboratory will work closely together with the applied research groups of Wageningen Food & Biobased Research, where direct translation towards application will be pursued with several industrial partners.

Functie-eisen

  • A solid background in Molecular Life Sicences, Biochemistry or Biotechnology with a MSc in Bioinformatics, Biotechnology, Bioprocess engineering or related fields;
  • a sound knowledge of microbial genetics, physiology and biochemistry;
  • computational competences in Python, Matlab and/or R;
  • experience in constraint-based metabolic modelling or machine learning will be a bonus;
  • fluent in English (both written and spoken).

Conditions

We offer a full-time position (38 hours), initially for 18 months after which a go/no go decision will be taken on an extension for an additional 30 months.

Gross salary per month € 2325,- in the first year rising to € 2972,- per month in the fourth year, in accordance with the Collective Labor Agreement Wageningen University (scale P).

In addition, we offer:
  • 8% holiday allowance;
  • a structural end-of year bonus of 8.3%;
  • excellent training opportunities and secondary employment conditions;
  • flexible working hours that we determine together in good consultation;
  • excellent pension plan through ABP;
  • 232 vacation hours, the option to purchase extra and good supplementary leave schemes, e.g.;
  • the possibility to work a maximum of 2 hours per week extra for extra leave;
  • a flexible model to put together part of your employment conditions yourself, such as a bicycle plan;
  • a lively workplace on the Wageningen Campus;
  • make use of the sports facilities on campus for a small fee.
Wageningen University & Research stimulates internal career opportunities and mobility with our internal recruitment policy. There are ample opportunities for personal initiative in a learning environment. With us you get a versatile job in an international environment with a pleasant and open working atmosphere.

Additional information

For more information about this position, please contact Prof. Vítor Martins dos Santos, chair Systems and Synthetic Biology, telephone number +31 317482865 or Prof Jeroen Hugenholtz, Groupleader Microbial Cell Factories, Wageningen Food & Biobased Research, telephone number +31 317485287.

For more information about the procedure you can contact Greetje van de Hulsbeek, HR advisor, e-mail: greetje.vandehulsbeek@wur.nl

Do you want to apply?
This can be done directly via the application button at the vacancy on our website so that we can process your personal data with your permission. This vacancy is open until Saturday 23rd May 2020.

Equal opportunities employer
We are an employer that offers equal opportunities. We are happy to receive applications from all suitably qualified people regardless of race, gender, functional impairment, religion / belief, sexual orientation or age.
We believe that a diverse and inclusive working environment makes us a more relevant, competitive and resilient organization. Click here for more information about working at WUR with a functional impairment.