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Researcher Antibody Discovery and Engineering

Do you have a passion for research and do you want to work with enthusiastic colleagues? And do you, as a researcher, want to contribute to our research? Then …

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Arbeidsvoorwaarden

Standplaats:
Droevendaalsesteeg, Wageningen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

Do you have a passion for research and do you want to work with enthusiastic colleagues? And do you, as a researcher, want to contribute to our research? Then we would like to talk to you! Read on and respond quickly!

Wageningen Bioveterinary Research has a project group that is working on llama single domain antibodies since 1995. These antibodies are generated by llama immunization, selected from phage display immune libraries and produced by expression in baker's yeast. This technique is applied within internal WUR projects in the field of therapy and diagnostics of infectious diseases as well as in contract research for various third parties. This work is done in collaboration with external or internal research groups with complementary expertise. To reduce the need of animal experiments, WBVR now aims to develop a novel non-immune llama single domain antibody phage display library.

Key Responsibilities of the researcher:
  • The design as well as synthesis of a large naïve and / or synthetic llama single domain antibody phage display library.
  • Evaluation of library quality by performing phage display selections and evaluation of isolated binders in various in vitro assays, including affinity assays using Octet.
  • A hands on mentality in the lab and supervision of one or more technicians.
  • Collaboration with a senior scientist and other team members to manage research projects on recombinant llama antibodies, including commercial projects for third parties.
  • Participate in client relations (reporting, discussion), write scientific publications, and participate in acquisition of novel projects in the field of recombinant (llama) antibody technology.

Functie-eisen

We are looking for someone who has a PhD in Biotechnology or associated field.

Technical/Functional Skills:

  • Relevant research experience in biotech, pharma or academia in recombinant antibody discovery and antibody engineering.
  • Proven solid technical expertise in generation and use of (conventional) antibody phage display libraries; expertise on generation and/or use of non-immune libraries and affinity maturation is preferred.
  • Expertise in analytical techniques like SDS-PAGE, Western blotting, affinity determination using Octet, ELISA etc.
  • Knowledge of basic bioinformatics tools preferably including MiSeq deep sequencing.
  • Good verbal and written communication skills including good interpersonal contact skills. Ability to establish and maintain effective working relationships with coworkers, managers and customers.
  • Effective time management and organizational skills; ability to manage several projects in parallel.
  • Good communication skills, including communicating results in spoken and written form, at least in English but preferably also in Dutch.
Because some of the work will take place in buildings with a specific biosafety classification, you will be subject to an additional quarantine restriction after leaving these buildings (based on EU regulations). This means that you will not be allowed to keep cloven-hoofed animals. You will also not be allowed to have contact with these animals or to visit poultry farms for 72 hours after working in such classified buildings.

Conditions

CAO WR
Wageningen University & Research offers excellent terms of employment. A few highlights from our Collective Labour Agreement include:
  • working hours that can be discussed and arranged so that they allow for the best possible work-life balance;
  • the option to accrue additional holiday hours by working more, up to 40 hours per week;
  • sabbatical leave, study leave, and paid parental leave;
  • there is a strong focus on vitality and you participate at the activities organized on-line;
  • a fixed December bonus of 3%;
  • a holiday allowance of 8%;
  • excellent training opportunities;
  • 171 vacation hours, the opportunity to buy additional and attractive additional leave arrangements;
  • an option model to determine part of your employment conditions yourself, e.g. a bicycle plan or the option to buy or sell vacation hours.
  • excellent pension scheme.
In addition to these first-rate employee benefits, you will of course receive a good salary. We offer, depending on your experience, a competitive gross salary of between € 3336,- and € 5183,- for a full-time working week of 36 hours, in accordance with the CLA Wageningen Research (scale 11). Initially, this position concerns a fixed-term employment for 1 year, with the option of extensio. WBVR is located in Lelystad, the Netherlands.

Wageningen University & Research encourages internal advancement opportunities and mobility with an internal recruitment policy. There are plenty of options for personal initiative in a learning environment, and we provide excellent training opportunities. We are offering a multi-faceted position in an international environment with a pleasant and open working atmosphere.

Coming from abroad
Wageningen University & Research is the university and research centre for life sciences. The themes we deal with are relevant to everyone around the world and Wageningen, therefore, has a large international community and a lot to offer to international employees. Applicants from abroad moving to the Netherlands may qualify for a special tax relief, known as the 30% ruling. Our team of advisors on Dutch immigration procedures will help you with the visa application procedures for yourself and, if applicable, for your family.
Feeling welcome also has everything to do with being well informed. Wageningen University & Research's International Community page contains practical information about what we can do to support international employees and students coming to Wageningen. Furthermore, we can assist you with any additional advice and information about helping your partner to find a job, housing, schooling, and other issues.

Additional information

Do you want more information?
For more information about this position, please contact Riks Maas, Department Head, phone number: +31(0)320-238891 oR Michiel Harmsen, phone number: +31(0)320-238436.

Procedure
A pre-employment screening may be part of the selection procedure. We ask for a Certificate of Conduct when entering employment.

Do you want to apply?
You can apply directly using the apply button on the vacancy page on our website which will allow us to process your personal information with your approval.
This vacancy will be listed up to and including August 29th, 2021. We hope to schedule the first job interviews soon after the closing date.

Equal opportunities
Wageningen University & Research (WUR) employs a large number of people with very different backgrounds and qualities, who inspire and motivate each other. We want every talent to feel at home in our organisation and be offered the same career opportunities. We therefore especially welcome applications from people who are underrepresented at WUR. For more information please go to our inclusivity page. A good example of how WUR deals with inclusiveness can be read on the page working at WUR with a functional impairment.