Ongeveer 17 uur geleden - VU - Amsterdam
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The Faculty of Science and the Leiden Academic Centre for Drug Research (LACDR) is looking for a PhD-candidate Chiral Metabolomics (1.0 FTE).
In present-day metabolomics, advanced analytical separation techniques are used for the global profiling of (endogenous) metabolites in biological samples. A major challenge, in this context, remains the highly sensitive and reliable analysis of metabolites in especially size-limited samples. Moreover, there is a strong need for analytical tools allowing chiral metabolomics studies, as chiral endogenous metabolites, such as for example D-amino acids and some D-organic acids, are more and more recognized as potential new biomarkers for the prediction and/or diagnosis of diseases. Therefore, the aim of this PhD project is to develop microscale analytical technologies for chiral metabolic profiling of especially small-volume biological samples. In this project, which is part of the Vidi-research program entitled “Enabling volume-restricted metabolomics using next-generation microscale analytical tools” from the Netherlands Organization for Scientific Research (NWO), capillary electrophoresis-mass spectrometry (CE-MS) will be considered as the main analytical platform for volume-restricted metabolomics. CE-MS method development for chiral metabolic profiling including utility assessment for relevant biomedical/clinical applications will be performed in close collaboration with Dr. Julie Schappler and Dr. Serge Rudaz from the Biomedical and Metabolomics Analysis group of the University of Geneva (UNIGE).
The PhD student is responsible for:
We offer a position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary ranges from €2,222 to €2,840 gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).
Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break. More at https://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditions.
The appointment should lead to a dissertation (PhD thesis). A training & supervision plan will be drafted, including attendance of courses and (international) meetings. The PhD-student is also expected to assist in teaching undergraduates.
All our PhD students are embedded in the Leiden University Graduate School of Science. Our Graduate School offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.
If you are interested in this position, you can contact Dr. Rawi Ramautar, group leader Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology of the LACDR, email firstname.lastname@example.org.
Your application should be addressed to Dr. Rawi Ramautar, email@example.com and must include:
Only applications received no later than 31 August 2018 can be considered. Only complete applications will be considered.
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