PhD position in the Biofabrication research group (1.0 FTE)
Come work in the ERC project 'Volumetric light-driven bioprinting capturing complex physiological shape, size and function in artificial tissues and organoids'
- Domplein, Utrecht, Utrecht
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 36 - 40 uur
- € 2395 - € 3061 per maand
The current job opportunity is supported by the European Research Council funded project entitled 'Volumetric light-driven bioprinting capturing complex physiological shape, size and function in artificial tissues and organoids' (VOLUME-BIO, ERC-StG, coordinated by Dr R. Levato).
Lab-made artificial tissues and organoids promise to revolutionize medicine, tackling transplant shortage, and to innovate biological and pharmaceutical research, introducing accurate in vitro models of human physiology, as potential alternatives to animal experimentation. The functionality of living organs is intimately linked to their complex architecture, from the physicochemical properties of extracellular microenvironment, to tissue-level scale, where multiple cell populations interact in a precisely orchestrated spatial distribution.
Advances in key technologies capturing this shape-function relationship in vitro can bring the long-sought goal of real tissue engineering within reach. In VOLUME-BIO, we will develop a novel volumetric bioprinting technology for the precise generation of engineered tissues with controlled mechano-chemical properties and organoids exhibiting physiological functions. Unlike conventional, layer-by-layer additive manufacturing, this new technique is able to generate complex, large-scale living tissue constructs with an unprecedented degree of fidelity and printing velocity (few seconds), by coordinating the projection of tomographic patterns of visible light onto photoresponsive materials.
Bringing together expertise in engineering, bioprinting, material design and stem cell biology, this project will first test the potential and versatility of this novel volumetric technology by building from anatomical, patient-specific images functional and centimeter-scale vascularized bone and bone marrow organoids, supporting physiological-like hematopoiesis.
You will become a member of the VOLUME-BIO team, embedded within the Utrecht Biofabrication research line. In particular, you will contribute to the goals of the project by focusing on the development of new photoresponsive materials and systems for the state-of-the-art volumetric bioprinting technology under development in our center. Both structural materials and innovative hydrogels that permit cell-driven tissue morphogenesis will be developed, thus requiring the targeting of very diverse chemical and physical properties, as well as the ability of such materials to respond dynamically to cell-induced stimuli. Interactions and collaboration with a multidisciplinary team of Clinicians, Biologists, Engineers and Veterinary Doctors form an essential part of the job.
You hold a Master’s degree in materials science, materials engineering, polymer chemistry, biomaterials, biofabrication, or a related area. You have proven expertise in materials synthesis, design and processing, with affinity for biology and biomedical sciences. You are a quick learner and you thrive in a multidisciplinary research environment. You are able to communicate effectively scientific ideas, foster collaboration and independent thinking. You are knowledgeable in your field and committed to keeping up with recent advances in literature. Experiences in photonics, 3D printing, engineering and tissue culture will be positively evaluated. Proven proficiency in written and spoken English is required.
A 4-year full-time PhD position in the interdisciplinary area of biomaterials, biofabrication and regenerative medicine. Your project will focus on the generation of advanced biomaterials using 3D-(bio)printing technologies. This position is hosted by Regenerative Medicine Utrecht and you will be appointed at Utrecht University (Faculty of Veterinary Medicine, Department of Clinical Sciences). You will be closely collaborating with other team members from the University Medical Center Utrecht of the Faculty of Pharmaceutical Sciences as well as with international partners of the Biofabrication research group within the Regenerative Medicine Center Utrecht.
We offer an exciting opportunity to contribute to an ambitious and international research programme with highly motivated students and to conduct your own research project at a renowned research university. You will receive appropriate training, personal supervision, and guidance for both your research and teaching tasks, which will provide an excellent start to an academic career.
We offer a temporary position (1.0 FTE), initially for a period of one year, which will be extended for an additional 3 years, in case of a good performance. The gross salary ranges between €2,395 in the first year and €3,061 in the fourth year (scale P according to the Collective Labour Agreement Dutch Universities) per month for a full-time employment. Salaries are supplemented with a holiday bonus of 8% and a year-end bonus of 8.3% per year. In addition, Utrecht University offers excellent secondary conditions, including an attractive retirement scheme, (partly paid) parental leave and flexible employment conditions (multiple choice model). More information about working at Utrecht University can be found here.