Ongeveer 20 uur geleden - VU - Amsterdam
Postdoctoral researcher in functional human neurogenomics
The research group Evolutionary Neurogenomics of the Swammerdam Institute for Life Sciences (SILS) works on elucidating the impact of human genome …
- Science Park, Amsterdam, Noord-Holland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 38 - 38 uur
- € 2709 - € 3895 per maand
The research group Evolutionary Neurogenomics of the Swammerdam Institute for Life Sciences (SILS) works on elucidating the impact of human genome evolution on human brain development and disorders and is looking for a postdoctoral researcher to strengthen our team.
This project is funded by the MGH Collaborative Center for X-Linked Dystonia-Parkinsonism (CCXDP). It will use my lab’s expertise in studying the evolutionary impact of retrotransposons, to unravel the mechanism of SVA-mediated misregulation of TAF1. We will use XDP patient-derived organoids to systematically investigate the mechanism through which the XDP-SVA affects the TAF1 locus. This knowledge will lead to a better understanding on XDP disease progression and may ultimately provide the first crucial steps that will guide the XDP community to develop potential therapeutic strategies in the future.
You will be carrying out transcriptomic and epigenetic profiling of XDP-patient derived iPSCs. This includes RNA-seq/ChIP-seq sample and sequencing library preparation as well as biocomputational analysis of the data. In addition, you will work closely together with a technician who will be in charge of most of the iPSC/organoid culturing.
- a PhD in biomedical sciences / (functional) genomics, preferentially with prior experience on mammalian (human) genomes;
- experience with all aspects of high throughput sequencing (such as RNA-seq/ ChIP-seq and post-sequencing biocomputational analysis;
- strong academic ambitions and wish to get experience in co-supervising other lab-members;
- excellent communication skills including a good command of the English language.
The appointment will be on a temporary basis for the period of 1 year. After satisfactory performance evaluation it will be extended with 1 more year to a total duration of 2 years. The monthly gross salary will be maximal €3,895 (scale 10-9) based on a full-time appointment and depending on relevant work experience. We offer a pension scheme, a holiday allowance of 8% per year, an end-of-year bonus of 8.3% and flexible employment conditions. Conditions are based on the Collective Labour Agreement of Dutch Universities.
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