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PhD position in computational single-cell cancer biology

Are you about to graduate from a quantitative MSc degree? Do you want to use your skills to develop novel computational methods to understand cancer cells at the single cell level? Do you want to work in a diverse team of scientists at the VU and The Netherlands Cancer Institute? Please apply at Vrije Universiteit Amsterdam.

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
De Boelelaan, Amsterdam, Noord-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
40 - 40 uur
Salarisindicatie:
€ 2395 - € 3061 per maand
Opleidingsniveau:
WO

Functieomschrijving

Technologies to measure the activity of many different signaling proteins at single cell resolution are revolutionizing cancer research. They give us new insights in cellular signal transduction, how this is aberrated in cancer, affected by anti-cancer drugs, and reveals the role of cell-to-cell variation. However, computational methods to analyze these data are lagging behind the technological developments. In this project, we will develop and apply computational methods to identify how differences between cells affect how they respond to drug treatment. To this end we will combine “snapshot” quantifications of many proteins simultaneously with live cell imaging data, and use these to build single cell statistical and mechanistic models of drug response. These models will be used to understand how cells respond and become resistant to anti-cancer drugs, which will help in designing more effective drug combinations.

This project will be jointly supervised by Dr. Evert Bosdriesz (evertbosdriesz.github.io),
Assistant Professor in the Integrative Bioinformatics group at the Vrije Universiteit
Amsterdam and Prof. Lodewyk Wessels, who heads the Computational Cancer Biology
group at the Netherlands Cancer Institute (ccb.nki.nl). The successful candidate will be
employed at the VU and will spend at least two days per week at the NKI.

Your duties

  • Develop computational methods to analyze high-dimensional single-cell protein activity data
  • Integrate such data with live-cell imaging data
  • Apply these methods to understand drug response and resistance in cancer cells
  • Communicate your work with both experimental biomedical researchers and bioinformaticians
  • Write a PhD thesis consisting of peer-reviewed scientific papers
  • Supervise computer practical’s to MSc students (<10% fte)

Functie-eisen

We are seeking a highly motivated PhD candidate with:

  • A degree in a quantitative discipline such as bioinformatics, computer science, physics or a related field
  • Experience in statistics, machine learning and/or pattern recognition
  • Proficiency in bioinformatics programming languages (e.g. R, Python)
  • Good cross-disciplinary collaborative and communication skills
  • Experience in analysing high-throughput molecular data is a plus
  • Experience in (cancer) biology and is a plus

Conditions

A challenging position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,395 (PhD) per month during the first year and increases to €3,061 (PhD) per month during the fourth year, based on a full-time employment. The job profile: PhD student, is based on the university job ranking system and is vacant for 1 FTE.

The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a duration of 3 years.
Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:
  • a maximum of 41 days of annual leave based on full-time employment
  • 8% holiday allowance and 8.3% end-of-year bonus
  • a wide range of sports facilities which staff may use at a modest charge

Additional information

Are you interested in this position? Please apply via the application button until January 24th, 2021 and upload the following:
  • Your CV including at least two references
  • A cover letter (CL) including a motivation for this PhD position and explaining how you fulfill the requirements for this position
  • BSc and MSc academic transcripts containing all your grades at university level
Applications received by e-mail will not be processed.

Vacancy questions
If you have any questions regarding this vacancy, you may contact:

Name: Evert Bosdriesz
Position: Assistant Professor
E-mail: e.bosdriesz@vu.nl

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