Ongeveer 4 uur geleden - Universiteit Maastricht (UM) - Maastricht
De PhD positie is beschikbaar bij de afdeling radiologie van het Nederlands Kanker Instituut (NKI-AvL) en de aanstelling vindt plaats bij de Universiteit Maast…
The PhD position is situated within the Groningen Institute for Evolutionary Life Sciences (GELIFES), in a collaboration between the groups Theoretical Research in Evolutionary Life Sciences (Prof Ido Pen) and Evolutionary Genetics, Development & Behaviour (Profs ...
The PhD position is situated within the Groningen Institute for Evolutionary Life Sciences (GELIFES), in a collaboration between the groups Theoretical Research in Evolutionary Life Sciences (Prof Ido Pen) and Evolutionary Genetics, Development & Behaviour (Profs Jean-Christophe Billeter and Ton Groothuis).
We are looking for a PhD candidate for the following research project:
Environmental predictability and the evolution of parental effects: integrating ecology, phylogeny, modelling and genetics
To predict how species will adapt in a rapidly changing world requires evolutionary models based on knowledge of developmental plasticity to various forms of environmental fluctuations. A hotly debated pathway of such plasticity is based on the transfer of non-genetic information from parents to offspring – known as parental effects. According to recent theoretical models, if parental and offspring environments are sufficiently alike, then the parental phenotype can be used as a source of information for offspring to adaptively match their environment. Thus, parental effects may play a crucial role in adaptation to changing environments. We will use a comparative approach to test this prediction in multiple Drosophila species, sampled globally from populations with different levels of similarity in ambient temperature between parental and offspring environments. We recently demonstrated adaptive parental effects in Drosophila melanogaster: the eggs of parents who reproduced at low or high temperatures survived better to adulthood when parental and offspring thermal conditions matched (both low or both high). Using similar experiments, we will quantify how parental effects affect adaptation in the sampled Drosophila populations. To test the theory, we will develop quantitative evolutionary models, taking into account observed population-specific demography and temperature fluctuations, and predict the relative importance of parental effects. Using genes discovered in our ongoing experimental evolution study on parental effects in D. melanogaster, we will compare sequence and structure of candidate genes underlying parental effects from the sampled populations. By thus integrating theory, ecology and genetics we will critically advance our understanding of transgenerational adaptive plasticity and quantify its importance for adaptation in a world with increasingly rapid changes in temperature.
We are looking for an ambitious candidate who preferably meets the following requirements:
• a master degree (preferably a research-oriented master) in biology
• affinity with both experimental work and mathematical/computer modelling
• preferentially experience in working with Drosophila and molecular genetics
• good communicative skills and independence in research in a practice setting, in close collaboration with others
• good oral and written command of the English language suited for scientific publications and conference presentations.
As a PhD candidate, you should be committed to conducting independent and original scientific research, to report on this research in international peer-reviewed publications, presentations, and disseminating knowledge in non-academic contexts. The result should be a cumulative PhD.
Faculty of Science and Engineering
Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative centre of higher education offering high-quality teaching and research. Balanced study and career paths in a wide variety of disciplines encourage the 30,000 students and researchers to develop their own individual talents. Belonging to the best research universities in Europe and joining forces with prestigious partner universities and networks, the University of Groningen is truly an international place of knowledge.
The Faculty of Science and Engineering harbours a kaleidoscope of disciplines and research strengths. Our programmes in research and education range from nanomaterials and biomachinery to astronomy, from mathematics to pharmacy, from neurosciences to computer science, and from molecular and evolutionary biology to marine biology. Our researchers pursue fundamental key questions while collaborating with partners from industry, the medical world and other realms of society. Frontline research groups explore new fields such as synthetic biology and sustainable energy use.
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