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  3. PhD candidate on the role of mitochondria in the eye disorder glaucoma

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PhD candidate on the role of mitochondria in the eye disorder glaucoma

The School for Mental Health of the Faculty of Health Medicine and Life Sciences has a job opening for a PhD candidate (biology, medical biology, biochemistry or related field) for a project on the role of mitochondria in the eye disorder glaucoma.

22 dagen geleden

Arbeidsvoorwaarden

Standplaats:
P Debyelaan, Maastricht, Limburg
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 40 uur
Salarisindicatie:
€ 2325 - € 2972 per maand
Opleidingsniveau:
WO

Functieomschrijving

The eye disorder glaucoma is the leading cause of irreversible blindness worldwide. Key event in the pathology is the death of retinal ganglion cells, which are the retinal neurons whose axons make up the optic nerve. This project focuses on the role of mitochondrial dysfunction in the death of these neurons and investigates whether bolstering mitochondrial activity by drugs or diet can protect them.

The studies will be performed using biomaterial of patients. First, the PhD student will characterize the study population genetically, focusing on polymorphisms in known glaucoma and mitochondrial genes. Next, the student will assess mitochondrial function using biochemical serum biomarkers and in vitro cellular assays. These assays employ PBMCs, fibroblasts as well as retinal cells generated via iPSCs of patients. Finally, the PhD student will test neuroprotective drugs in these assays.

This project will be performed at the University of Maastricht. It is a joined effort of the University Eye Clinic Maastricht (Prof. dr. C. Webers, dr. T. Gorgels) and the Department of Cell Biology, a leading expert on mitochondrial disorders (Prof. dr. H. Smeets). These institutes collaborate within the research school of Mental Health and Neuroscience (MHeNs).

Functie-eisen

  • MSc degree in biology, biochemistry, medicine or related field.
  • Experience with cell culture, preferentially with iPSCs
  • Affinity with genetics and cell biology in general and mitochondria in particular.
  • Excellent communication skills since the team members have diverse backgrounds.
  • Motivated by translational research with clinical applications
  • Fluent in English

Conditions

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website http://www.maastrichtuniversity.nl > Support > UM employees.

Successful candidates will be offered contracts on the appropriate scale of the CAO UM.

Additional information

For information please contact dr. Theo Gorgels, theo.gorgels@mumc.nl

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